THE ROLE OF ENVIRONMENTAL TOXINS IN THE ETIOLOGY OF PARKINSONS-DISEASE
THE ROLE OF ENVIRONMENTAL TOXINS IN THE ETIOLOGY OF PARKINSONS-DISEASE
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DOI：
10.1016/0166-2236(89)90135-5
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发表时间：
1989-02-01
影响因子：
15.9
通讯作者：
TANNER, CM
中科院分区：
文献类型：
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作者：
TANNER, CM
由吡啶MPTP的帕金森综合征的生产惊人地类似于“特发性”疾病，以及缺乏证据支持帕金森病（PD）的遗传性或感染性病因，刺激了寻找类似MPTP的环境化学物质，可能会导致PD。为了支持这一点，描述性流行病学研究发现，在高度工业化的国家，PD的患病率较高。在北美和欧洲，早发性PD似乎与农村居住有关。与此相关的因素包括蔬菜种植、饮用井水、木浆、造纸和钢铁工业。在中国，生活在工业化的城市地区会增加患PD的风险。帕金森病（Parkinson's disease，PD）是最常见的神经退行性疾病之一，其发病机制尚不清楚，但环境中的化学物质可能与PD的发生发展有关。PD曾被认为是1917-1926年脑炎流行期间感染的后遗症，但近年来发病率并未下降，这一假设站不住脚。最近，静脉注射毒性哌替啶衍生物1-甲基-1，2，3，6-四氢吡啶（MPTP）导致强烈类似PD的帕金森综合征。毒素诱导的综合征的临床和病理学上类似于自然发生的疾病的生产导致的假设，环境毒素可能同样是病因学相关的PD。本文总结了尝试使用现有知识的PD预测环境致病因素的身份，并回顾了最近的研究，在寻找这样的环境因素。
The production by the pyridine MPTP of a parkinsonian syndrome strikingly similar to the'idiopathic'disorder, and the paucity of evidence supporting a hereditary or infectious etiology for Parkinson's disease (PD), have stimulated a search for environmental chemicals resembling MPTP that might cause PD. In support of this, descriptive epidemiological studies have found higher preva/ences of PD in highly industrialized countries. In North America and Europe, early onset PD appears to be associated with rural residence. Factors associated with this include vegetable farmin E, well water drinking, wood pulp, paper and steel industries. In China, living in industrialized urban areas increases the risk of developing PD. Preliminary epidemiologica/evidence supports the hypothesis that environmental chemicals may be related to the development of PD, but specific chemicals and their specific mechanism (s) have not been identified.The cause of Parkinson's disease (PD), one of the most common of the neurodegenerative disorders, is unknown. PD was once felt to be the sequela of infection during the encephalitis epidemics of 1917-1926, but disease incidence has not decreased in recent years, rendering this postulate untenable. Recently, a parkinsonian syndrome strongly resembling PD resulted from the intravenous injection of a toxic meperidine derivative, 1-methyl-l, 2, 3, 6-tetrahydropyridine (MPTP). The toxin-induced production of a syndrome clinically and pathologically resembling the naturally occurring disease led to the postulate that environmental toxins might similarly be etiologically related to PD. This article summarizes attempts to use current knowledge of PD to predict the identity of environmental etiological factors, and reviews recent studies in search of such environmental factors.