Nasal and nasal-type natural killer T-cell lymphoma
Nasal and nasal-type natural killer T-cell lymphoma
复制标题
DOI：
10.1016/s0190-9622(99)70204-5
复制
发表时间：
1999-02-01
影响因子：
13.8
通讯作者：
Arata, J
中科院分区：
文献类型：
--
作者：
Hirakawa, S;Kuyama, H;Arata, J
鼻和鼻型自然杀伤（NK）/T细胞淋巴瘤遵循一个积极的过程，并有一个不良的预后。最近的病理学研究表明，该疾病是NK细胞的恶性增殖，其通常表达CD 56。与EB病毒的关联也有报道。研究的3例患者均发生皮肤受累。放射治疗在早期阶段为患者提供了一些益处。常规化疗无效。为了克服肿瘤细胞的多重耐药，我们采用环孢霉素和大剂量化疗联合外周血干细胞移植的方法，患者从发病开始的平均生存期为9.6个月。鼻和鼻型NK/T细胞淋巴瘤的管理需要进一步改进。
Nasal and nasal-type natural killer (NK)/T-cell lymphomas follow an aggressive course and have a poor prognosis. Recent pathologic studies suggest that the disease is a malignant proliferation of NK cells, which often express CD56. An association with the Epstein-Barr virus has also been reported. Skin involvement occurred in each of the 3 patients studied. Radiation therapy provided some benefit to the patients in the early stages. Conventional chemotherapies were not effective. To overcome this multiple-drug resistance of the tumor cells, cyclosporine and high-dose chemotherapy was combined with peripheral-blood stem-cell transplantation, The average life span from the onset of the disease for our patients was 9.6 months. Further improvement in the management of nasal and nasal-type NK/T-cell lymphomas is necessary.