Dopant for detection of methamphetamine in the presence of nicotine with ion mobility spectrometry
Dopant for detection of methamphetamine in the presence of nicotine with ion mobility spectrometry
复制标题
使用离子迁移谱法在尼古丁存在下检测甲基苯丙胺的掺杂剂
DOI：
10.1007/s00216-021-03370-z
复制
发表时间：
2021-05-04
影响因子：
4.3
通讯作者：
Chu, Yannan
中科院分区：
文献类型：
--
作者：
Liu, Hui;Xia, Lei;Chu, Yannan
甲基苯丙胺（MA）是一种高度成瘾性的非法精神兴奋药物，目前是世界上最常滥用的非法药物之一。现场快速检测痕量 MA 并在秘密实验室筛查非法药物对于缉毒机构和整个法医界非常重要。然而，由于甲基苯丙胺和尼古丁的光谱峰重叠，通过离子迁移谱法检测存在尼古丁和香烟烟雾的甲基苯丙胺面临困难。在这项工作中，开发了一种在尼古丁存在下通过自制离子淌度光谱法以吡啶作为掺杂剂检测MA的新方法。在 40 至 120 °C 的漂移管温度下并掺杂吡啶，测量了 MA 和尼古丁的降低迁移率。结果表明，100℃的温度有利于两种物质的分解。掺杂吡啶的浓度优化为 18 ppm。在该掺杂实验中，通过测量MA和尼古丁的仪器反应，尼古丁的反应速率高于MA。无论尼古丁含量多高，在检测掺杂吡啶的MA时都可以消除尼古丁的干扰。该方法还成功应用于真实唾液样品中MA和尼古丁的同时测定。 MA 的检测限约为 0.5 ng/μL。这项工作的良好结果为MA的现场检测提供了一种有效的方法。图文摘要
Methamphetamine (MA) is a highly addictive and illegal psychostimulant drug and is currently one of the most commonly abused illicit drugs in the world. The on-site rapid detection of trace amounts of MA and screening illicit drugs in clandestine laboratories is important for drug enforcement agencies and the forensic community in general. However, detecting methamphetamine in the presence of nicotine and cigarette smoke by ion mobility spectrometry faces difficulty due to the overlapped spectral peaks of methamphetamine and nicotine. In this work, a new method was developed to detect MA using pyridine as a dopant in the presence of nicotine by a homemade ion mobility spectrometry. The reduced mobilities of MA and nicotine were measured under the temperatures of the drift tube from 40 to 120 °C and doping with pyridine. The result shows that the temperature of 100 °C is beneficial to resolve the two substances. The concentration of doped pyridine is optimized to be 18 ppm. In this doped experiment, the reaction rate of nicotine is higher than that of MA by measuring the instrumental responses of MA and nicotine. No matter how high the nicotine content is, the interference of nicotine can be eliminated in the detection of MA doped with pyridine. This method is also successfully applied for the determination of MA and nicotine simultaneously in real saliva samples. The limit of detection of MA was measured to be about 0.5 ng/μL. The promising results in this work provide an effective method for on-site detection of MA.Graphical abstract