High resolution measurement of cerebral blood flow using intravascular tracer bolus passages .2. Experimental comparison and preliminary results.
High resolution measurement of cerebral blood flow using intravascular tracer bolus passages .2. Experimental comparison and preliminary results.
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DOI：
10.1002/mrm.1910360511
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发表时间：
1996-11-01
影响因子：
3.3
通讯作者：
Rosen, BR
中科院分区：
文献类型：
--
作者：
Ostergaard, L;Sorensen, AG;Rosen, BR
本报告评价了几种方法来映射相对脑血流量（rCBF），通过应用参数和非参数技术来反卷积顺磁团通道的高分辨率动态MRI测量值与非侵入性确定的动脉输入，我们发现了一个非参数（奇异值分解（SVD））反卷积技术产生最稳健的结果，给出平均灰度：6名正常志愿者的白色血流比为2.7 +/- 0.5（SEM），与年龄匹配受试者的最新PET文献值非常一致。通过使用模型依赖性方法获得了类似的结果，该方法假设指数残数函数，但不适用于高斯形状残数函数或基于傅立叶或正则化的模型独立方法。我们的CBF映射技术在肿瘤患者中的初步研究，中风和偏头痛先兆表明，这些技术可以很容易地用于通过使用当前回波平面成像技术常规采集的数据，通过使用这些技术，作者可视化了rCBV标测算法无法检测到的重要局部血流动力学变化。
This report evaluates several methods to map relative cerebral blood flow (rCBF) by applying both parametric and nonparametric techniques to deconvolve high resolution dynamic MRI measurements of paramagnetic bolus passages with noninvasively determined arterial inputs, We found a nonparametric (singular value decomposition (SVD)) deconvolution technique produced the most robust results, giving mean gray:white flow ratio of 2.7 +/- 0.5 (SEM) in six normal volunteers, in excellent agreement with recent PET literature values for age-matched subjects. Similar results were obtained by using a model-dependent approach that assumes an exponential residue function, but not for a Gaussian-shaped residue function or for either Fourier or regularization-based model-independent approaches, Pilot studies of our CBF mapping techniques in patients with tumor, stroke, and migraine aura demonstrated that these techniques can be readily used on data routinely acquired by using current echo planar imaging technology, By using these techniques, the authors visualized important regional hemodynamic changes not detectable with rCBV mapping algorithms.