Metallic Scaffolds for Bone Regeneration
Metallic Scaffolds for Bone Regeneration
复制标题
DOI：
10.3390/ma2030790
复制
发表时间：
2009-07-23
期刊：
影响因子：
3.4
通讯作者：
Nakajima H
中科院分区：
文献类型：
--
作者：
Alvarez K;Nakajima H
骨组织工程是一个新兴的跨学科领域的科学，结合专业知识，在医学，材料科学和生物力学。硬组织工程的研究主要集中在两个领域，骨和牙科临床应用。全球范围内正在进行许多令人兴奋的研究，以开发用于组织工程的新型支架。虽然，现在大部分的研究工作是在非承重应用的支架的发展，主要使用软的天然或合成聚合物或天然支架的软组织工程;金属支架的目的是硬组织工程也一直在体外和体内的研究和工业发展的主题。在这篇文章中，描述了不同的制造技术，可用于制造金属支架和编译的报告，目前开发的金属支架的生物相容性已经执行。最后，我们强调了积极的方面和剩余的问题，将推动未来的研究，旨在重建和修复骨的金属结构。
Bone tissue engineering is an emerging interdisciplinary field in Science, combining expertise in medicine, material science and biomechanics. Hard tissue engineering research is focused mainly in two areas, osteo and dental clinical applications. There is a lot of exciting research being performed worldwide in developing novel scaffolds for tissue engineering. Although, nowadays the majority of the research effort is in the development of scaffolds for non-load bearing applications, primarily using soft natural or synthetic polymers or natural scaffolds for soft tissue engineering; metallic scaffolds aimed for hard tissue engineering have been also the subject of in vitro and in vivo research and industrial development. In this article, descriptions of the different manufacturing technologies available to fabricate metallic scaffolds and a compilation of the reported biocompatibility of the currently developed metallic scaffolds have been performed. Finally, we highlight the positive aspects and the remaining problems that will drive future research in metallic constructs aimed for the reconstruction and repair of bone.