Micromanagement of the mitochondrial apoptotic pathway by p53
Micromanagement of the mitochondrial apoptotic pathway by p53
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DOI：
10.2741/3717
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发表时间：
2011-01-01
影响因子：
3.1
通讯作者：
Elble, Randolph
中科院分区：
文献类型：
--
作者：
Walia, Vijay;Kakar, Smita;Elble, Randolph
现在已经确定p53是应激反应的主要仲裁者，也是细胞水平上肿瘤过程的主要屏障。也许p53的肿瘤抑制武器库中最有力的武器是细胞凋亡，当所有其他补救措施都用尽时，作为最后的手段。最初，该机制被认为是p53简单地激活或抑制Bcl-2家族成员。最近，出现了一种更快速的途径的证据，即p53与Bcl-2家族成员物理相互作用，使平衡向凋亡倾斜。这篇综述详细介绍了p53对细胞凋亡的多层次调控，包括最近的研究结果，p53易位是如何调控的。
It is now well established that p53 is the primary arbiter of stress-response and the principal barrier to neoplastic processes at the cellular level. Perhaps the most potent weapon in p53's tumor suppressive arsenal is apoptosis, enacted as a last resort when all other remedies are exhausted. Initially, the mechanism was thought to be simply activation or repression of Bcl-2 family members by p53. More recently, evidence of a more rapid pathway emerged whereby p53 physically interacts with Bcl-2 family members to tip the balance toward apoptosis. This review details the multiple levels of regulation of mitochondrially-directed apoptosis by p53, including recent findings of how p53 translocation is regulated.