The mechanisms of Mallory-Denk body formation are similar to the formation of aggresomes in Alzheimer's disease and other neurodegenerative disorders.
The mechanisms of Mallory-Denk body formation are similar to the formation of aggresomes in Alzheimer's disease and other neurodegenerative disorders.
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DOI：
10.1016/j.yexmp.2016.03.010
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发表时间：
2016-06
影响因子：
3.6
通讯作者：
Peng Y
中科院分区：
文献类型：
--
作者：
French SW;Mendoza AS;Peng Y
在阿尔茨海默病(AD)等神经退行性疾病的大脑中形成的攻击体，以及在Mallory-Denk小体(MDB)等形成攻击体的肝脏中形成的攻击体，可能具有相同的机制。可以通过给小鼠喂食腺苷蛋氨酸或甜菜碱来预防MDB。这些蛋白质可能可以预防AD。我们比较了有关MDBS和AD发病机制的文献，包括p62、泛素UBB+1、HSPs70、90、104、FAT10、NEDD8、VCP/97，以及蛋白质质量控制机制，包括26S蛋白酶体、iPod和JUNQ以及自噬菌体通路。
There is a possibility that the aggresomes that form in the brain in neurodegenerative diseases like Altzheimer’s disease (AD) and in the liver where aggresomes like Mallory-Denk Bodies (MDB) form, share mechanisms. MDBs can be prevented by feeding mice sadenosylmethionine (SAMe) or betaine. Possibly these proteins could prevent AD. We compared the literature on MDBs and AD pathogenesis, which include roles played by p62, ubiquitin UBB+1, HSPs70, 90, 104, FAT10, NEDD8, VCP/97, and the protein quality control mechanisms including the 26s proteasome, the IPOD and JUNQ and autophagasome pathways.