A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells
A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells
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DOI：
10.1016/s0161-5890(00)00067-5
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发表时间：
2000-06-01
影响因子：
3.6
通讯作者：
Takahashi, TA
中科院分区：
文献类型：
--
作者：
Ohno, M;Hirata, T;Takahashi, TA
白细胞趋化因子通过G蛋白偶联受体参与炎症反应。我们报告了一个新的人类基因的克隆编码的假定孤儿受体，C5 L2，属于一个亚家族的C3 a，C5 a和甲酰基Met-Leu-Ph受体，相关的趋化因子受体家族。C5 L2转录水平丰富的粒细胞和未成熟的树突状细胞，但不是在成熟的树突状细胞。我们推测这种受体可能调节未成熟树突状细胞的激活，并在白细胞对炎症区域的化学吸引中发挥作用。(C)2000爱思唯尔科技有限公司版权所有。
Leukocyte chemoattractants are involved in the inflammatory response act via G protein-coupled receptors. We report the cloning of a novel human gene encoding the putative orphan receptor, C5L2, belonging to a subfamily of C3a, C5a and formyl Met-Leu-Ph receptors that are related to the chemokine receptor family. C5L2 transcript levels were abundant in granulocytes and immature dendritic cells but not in mature dendritic cells. We speculate that this receptor may regulate the activation of immature dendritic cells and play a role in the chemoattraction of leukocytes to inflammatory regions. (C) 2000 Elsevier Science Ltd. All rights reserved.