Comparative Effects of Two Gingerol-Containing Zingiber officinale Extracts on Experimental Rheumatoid Arthritis
Comparative Effects of Two Gingerol-Containing Zingiber officinale Extracts on Experimental Rheumatoid Arthritis
复制标题
DOI：
10.1021/np8006183
复制
发表时间：
2009-03-01
影响因子：
5.1
通讯作者：
Timmermann, Barbara N.
中科院分区：
文献类型：
--
作者：
Funk, Janet L.;Frye, Jennifer B.;Timmermann, Barbara N.
生姜（Zingiber officinale）补充剂在西方社会被推广用于治疗关节炎，其基础是生姜在中国和印度草药中作为抗炎药的传统用途。然而，生姜抗关节炎作用的科学证据很少，其生物活性的关节保护成分尚未被确定。因此，在类风湿关节炎（链球菌细胞壁引起的关节炎）动物模型中，我们比较了具有良好特征的粗姜提取物抑制关节肿胀的能力，并将其与仅含有姜辣素及其衍生物的提取物进行了比较。两种提取物均能有效预防关节炎症。然而，粗二氯甲烷提取物也含有精油和更多极性化合物，在预防关节炎症和破坏方面更有效（当与姜辣素含量标准化时）。综上所述，这些数据证明了这些姜样品具有非常显著的关节保护作用，并表明非姜酚成分具有生物活性，可以增强被广泛研究的姜酚的抗关节炎作用。
Ginger (Zingiber officinale) supplements are being promoted for arthritis treatment in western societies on the basis of ginger's traditional use as an anti-inflammatory in Chinese and Ayurvedic medicine. However, scientific evidence of ginger's antiarthritic effects is sparse, and its bioactive joint-protective components have not been identified. Therefore, the ability of a well-characterized crude ginger extract to inhibit joint swelling in an animal model of rheumatoid arthritis, streptococcal cell wall-induced arthritis, was compared to that of a fraction containing only gingerols and their derivatives. Both extracts were efficacious in preventing joint inflammation. However, the crude dichloromethane extract, which also contained essential oils and more polar compounds, was more efficacious (when normalized to gingerol content) in preventing both joint inflammation and destruction. In conclusion, these data document a very significant joint-protective effect of these ginger samples and suggest that nongingerol components are bioactive and can enhance the antiarthritic effects of the more widely studied gingerols.