SIRT1: new avenues of discovery for disorders of oxidative stress.
SIRT1: new avenues of discovery for disorders of oxidative stress.
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DOI：
10.1517/14728222.2012.648926
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发表时间：
2012-02
影响因子：
5.8
通讯作者：
Maiese K
中科院分区：
文献类型：
--
作者：
Chong ZZ;Shang YC;Wang S;Maiese K
Sirtuin SIRT1在全身表达，具有广泛的生物学效应，在急性和长期损伤中可以显著影响细胞的存活和寿命，包括氧化应激和细胞代谢。SIRT1在多种疾病的病理、进展和治疗中扮演着复杂的角色，包括阿尔茨海默病和帕金森病等神经退行性疾病、肿瘤发生、伴有心肌损伤和动脉粥样硬化的心血管疾病、代谢性疾病和衰老相关疾病。重点介绍了这些学科的新研究领域，以及对细胞生物学的讨论。针对SIRT1的新的信号通路不断涌现，这些信号通路可以增强细胞保护，并有可能延长寿命。可以进一步确定SIRT1在各种细胞系统和环境中发生的细胞内信号、运输和翻译后修饰的研究将使我们能够进一步将这些知识转化为适用于身体多个系统的有效治疗策略。
The sirtuin SIRT1 is expressed throughout the body, has broad biological effects and can significantly affect both cellular survival and longevity during acute and long-term injuries, which involve both oxidative stress and cell metabolism. SIRT1 has an intricate role in the pathology, progression, and treatment of several disease entities, including neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, tumorigenesis, cardiovascular disease with myocardial injury and atherosclerosis, metabolic disease, and aging-related disease. New areas of study in these disciplines, with discussion of the cellular biology, are highlighted. Novel signaling pathways for SIRT1, which can be targeted to enhance cellular protection and potentially extend lifespan, continue to emerge. Investigations that can further determine the intracellular signaling, trafficking and post-translational modifications that occur with SIRT1 in a variety of cell systems and environments will allow us to further translate this knowledge into effective therapeutic strategies that will be applicable to multiple systems of the body.
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影响因子：
2.1
作者：
Chong ZZ;Maiese K
通讯作者：
Maiese K
影响因子：
9.8
作者：
Bordone L;Motta MC;Picard F;Robinson A;Jhala US;Apfeld J;McDonagh T;Lemieux M;McBurney M;Szilvasi A;Easlon EJ;Lin SJ;Guarente L
通讯作者：
Guarente L
影响因子：
4.8
作者：
Balan, Vitaly;Miller, Gregory S.;Tzivion, Guri
通讯作者：
Tzivion, Guri
影响因子：
4.7
作者：
Albani, Diego;Polito, Letizia;Forloni, Gianluigi
通讯作者：
Forloni, Gianluigi
影响因子：
3.6
作者：
Cheng, TH;Liu, JC;Chen, JJ
通讯作者：
Chen, JJ