Relations between dairy product intake and blood pressure: the INTERnational study on MAcro/micronutrients and blood Pressure.
Relations between dairy product intake and blood pressure: the INTERnational study on MAcro/micronutrients and blood Pressure.
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DOI：
10.1097/hjh.0000000000001779
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发表时间：
2018-10
影响因子：
4.9
通讯作者：
INTERMAP Research Group
中科院分区：
文献类型：
--
作者：
Aljuraiban GS;Stamler J;Chan Q;Van Horn L;Daviglus ML;Elliott P;Oude Griep LM;INTERMAP Research Group
流行病学证据表明，低脂乳制品消费可能会降低高血压的风险。由于营养成分的差异，乳制品可能与健康有明显的联系，但对导致乳血压（BP）关联的特定营养素知之甚少，也不知道潜在的肾功能。我们从MAcro/微量营养素和血压的国际研究（INTERMAP）中研究了乳制品摄入量与血压的横截面关联，包括来自英国和美国的2694名40- 59岁的参与者。在四次访视期间收集了八个BP，四个24小时饮食回忆和两个24小时尿液样本。调整生活方式/饮食因素的线性回归模型，以估计每2SD的总和个人类型的乳制品摄入量较高的血压差异进行计算。估计并合并多变量线性回归系数。与全脂和全脂乳制品相比，每增加195 g/1000 kcal（2SD）的低脂乳制品摄入量与较低的SBP-2.31 mmHg和DBP-2.27 mmHg相关。调整膳食磷、钙和乳糖后，显著相关性减弱，但调整尿钙后显著相关性增强。按白蛋白-肌酐比值中位数（ACR;高ACR表明肾功能受损）分层显示，低ACR参与者的低脂乳制品与血压之间存在强相关性（SBP：-3.66; DBP：-2.15 mmHg），而高ACR参与者则无相关性。低脂乳制品消费与较低的血压相关，特别是在低ACR的参与者中。富含磷和钙的乳制品营养素可能有助于与BP的有益联系。
Epidemiologic evidence suggests that low-fat dairy consumption may lower risk of hypertension. Dairy products may be distinctly linked to health, because of differences in nutritional composition, but little is known about specific nutrients that contribute to the dairy-blood pressure (BP) association, nor to underlying kidney function. We examined cross-sectional associations to BP of dairy product intakes, total and by type, from the INTERnational study on MAcro/micronutrients and blood Pressure (INTERMAP) including 2694 participants aged 40– 59 years from the UK and the USA. Eight BP, four 24-h dietary recalls and two 24-h urine samples were collected during four visits. Linear regression models adjusted for lifestyle/dietary factors to estimate BP differences per 2SD higher intakes of total-and-individual-types of dairy were calculated. Multivariable linear regression coefficients were estimated and pooled. In contrast to total and whole-fat dairy, each 195 g/1000 kcal (2SD) greater low-fat dairy intake was associated with a lower SBP −2.31 mmHg and DBP −2.27 mmHg. Significant associations attenuated with adjustment for dietary phosphorus, calcium, and lactose, but strengthened with urinary calcium adjustment. Stratification by median albumin–creatinine ratio (ACR; high ACR indicates impaired kidney function) showed strong associations between low-fat dairy and BP in participants with low ACR (SBP: −3.66; DBP: −2.15 mmHg), with no association in participants with high ACR. Low-fat dairy consumption was associated with lower BP, especially among participants with low ACR. Dairy-rich nutrients including phosphorus and calcium may have contributed to the beneficial associations with BP.