Novel and efficient MR active aqueous colloidal Fe3O4 nanoassemblies
Novel and efficient MR active aqueous colloidal Fe3O4 nanoassemblies
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DOI：
10.1039/b911626e
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发表时间：
2009-01-01
影响因子：
--
通讯作者：
Dravid, Vinayak P.
中科院分区：
文献类型：
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作者：
Barick, K. C.;Aslam, M.;Dravid, Vinayak P.
这项工作展示了一类新的磁共振（MR）活性的水性Fe 3 O 4磁性纳米粒子纳米组装体（Fe 3 O 4 MNNA）的类似40 nm的大小，包括类似6 nm的颗粒。与6 nm分离的对应物（Fe 3 O 4 MNP）和商业造影剂ferumoxytol相比，它们在T-2 MR对比度方面表现出增强。T-2 MR信号的显著改善源于组装在Fe 3 O 4 MNNA中的多个Fe 3 O 4纳米颗粒的协同磁性。这些纳米组装体还显示出更好的胶体稳定性、更高的磁化强度、良好的比吸收率（在外部AC磁场下）和与细胞的细胞相容性。此外，Fe 3 O 4颗粒表面上存在的官能团（-NH 2）可以通过成熟的生物缀合化学用于生物分子的常规缀合。具体而言，一种新的MR活性的胶体胺功能化的Fe 3 O 4纳米组装与增强的T-2对比度性能已被制造，这也可以被用作一个有效的热源热疗治疗癌症。
This work demonstrates a new class of magnetic resonance (MR) active aqueous Fe3O4 magnetic nanoparticle nanoassemblies (Fe3O4 MNNA) of similar to 40 nm size comprising similar to 6 nm particles. They exhibit enhancement in T-2 MR contrast as compared to 6 nm isolated counterparts (Fe3O4 MNP) and commercial contrast agent, ferumoxytol. This significant improvement in the T-2 MR signal arises from the synergistic magnetism of multiple Fe3O4 nanoparticles assembled in Fe3O4 MNNA. These nanoassemblies also show better colloidal stability, higher magnetization, good specific absorption rate (under external AC magnetic field) and cytocompatibility with cells. Further, the functional groups (-NH2) present on the surface of Fe3O4 particles can be accessible for routine conjugation of biomolecules through well-developed bioconjugation chemistry. Specifically, a new MR active colloidal amine-functionalized Fe3O4 nanoassembly with enhanced T-2 contrast properties has been fabricated, which can also be used as an effective heating source for hyperthermia treatment of cancer.