Association between ABO Blood Group and Risk of Congenital Heart Disease: A 6-year large cohort study.
Association between ABO Blood Group and Risk of Congenital Heart Disease: A 6-year large cohort study.
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ABO 血型与先天性心脏病风险之间的关联：一项为期 6 年的大型队列研究
DOI：
10.1038/srep42804
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发表时间：
2017-02-17
影响因子：
4.6
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Zu B;You G;Fu Q;Wang J
ABO血型除了对输血和器官移植有直接的临床意义外，一般认为是冠心病的影响因素，但ABO血型与先天性心脏病（CHD）的关系尚不明确。在这项研究中，我们评估了ABO血型与CHD风险的潜在关系。在39，042例连续住院患者（19，795例CHD VS 19，247例对照）中，我们使用多变量logistic回归来评估ABO血型、性别和RH对CHD的作用。ABO血型与CHD亚组之间的关系通过分层分析进一步评估，并按性别进行调整。在整个队列分析中，A血型个体的孤立性CHD风险降低（OR 0.82; 95%CI，0.78-0.87），并且在独立亚组分析中一致重复了这一发现。ABO血型可能与冠心病有关，这一新发现为ABO血型作为冠心病的一个可能标志物提供了新的思路，但仍需进一步研究。
ABO blood group, except its direct clinical implications for transfusion and organ transplantation, is generally accepted as an effect factor for coronary heart disease, but the associations between ABO blood group and congenital heart disease (CHD) are not coherent by previous reports. In this study, we evaluated the the potential relationship between ABO blood group and CHD risk. In 39,042 consecutive inpatients (19,795 CHD VS 19,247 controls), we used multivariable logistic regression to evaluate the roles of ABO blood group, gender, and RH for CHD. The associations between ABO blood group and CHD subgroups, were further evaluated using stratification analysis, adjusted by gender. A blood group demonstrated decreased risk for isolated CHD (OR 0.82; 95% CI, 0.78–0.87) in individuals with A blood group in the overall cohort analysis, and the finding was consistently replicated in independent subgroup analysis. ABO blood group may have a role for CHD, and this novel finding provides ABO blood group as a possible marker for CHD, but more studies need to be done.
DOI：
10.1155/2013/406209
发表时间：
2013
期刊：
International journal of evolutionary biology
影响因子：
--
作者：
Itou M;Sato M;Kitano T
通讯作者：
Kitano T