LONG-TERM EFFECTS OF THE MENOPAUSE AND SEX-HORMONES ON SKIN THICKNESS
LONG-TERM EFFECTS OF THE MENOPAUSE AND SEX-HORMONES ON SKIN THICKNESS
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DOI：
10.1111/j.1471-0528.1985.tb01091.x
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
VERSI, E
中科院分区：
文献类型：
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作者：
BRINCAT, M;MONIZ, CJ;VERSI, E
将接受性激素植入治疗的绝经后妇女组的皮肤胶原蛋白含量和皮肤厚度与未接受治疗的类似妇女组进行比较。发现治疗组的皮肤胶原蛋白含量和厚度均显着高于未治疗组。在未经治疗的女性中，皮肤胶原蛋白含量下降与绝经年龄有关，但与实际年龄无关。在治疗组中未发现与绝经年龄、实际年龄或治疗持续时间相关。显然，皮肤胶原蛋白受到性激素状态的影响，并在绝经后下降，导致据报道此时发生的尿羟脯氨酸排泄增加。
Skin collagen content and skin thickness in a group of postmenopausal women who were treated with sex hormone implants were compared with those in an untreated group of similar women. Both skin collagen content and thickness were found to be significantly greater in the treated than in the untreated group. In the untreated women skin collagen content declined in relation to menopausal age but not to chronological age. No correlation was found with menopausal age, chronological age or duration of therapy in the treated group. Evidently, skin collagen is influenced by the sex hormone status and declines after the menopause, contributing to the increase in urinary hydroxyproline excretion that was reported to occur at this time.