Simple Cancer Stem Cell Markers Predict Neoadjuvant Chemotherapy Resistance of Esophageal Squamous Cell Carcinoma
Simple Cancer Stem Cell Markers Predict Neoadjuvant Chemotherapy Resistance of Esophageal Squamous Cell Carcinoma
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DOI：
10.21873/anticanres.15214
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发表时间：
2021-08-01
影响因子：
2
通讯作者：
Kakeji, Yoshihiro
中科院分区：
文献类型：
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作者：
Agawa, Kyosuke;Yamashita, Kimihiro;Kakeji, Yoshihiro
背景/目的：食管鳞状细胞癌（ESCC）中肿瘤干细胞（CSC）参与了对新辅助化疗（NAC）的抵抗。我们进行了一项回顾性观察性研究，探讨5-氟尿嘧啶加顺铂（FP）-NAC治疗前活检标本中CSC标志物的表达水平与病理反应之间的关系。患者和方法：我们纳入了171例ESCC患者，他们接受了FP-NAC，随后进行了根治性切除。在FP-NAC之前获得活检标本，并对CD 44、CD 133和CD 24进行免疫化学染色。结果如下：无应答者的活检标本具有高水平的CD 44（高）/CD 24（低）表达，多变量分析发现这不仅是FP-NAC耐药的独立预测因子，而且是总体生存率差的独立预测因子。结论：CD 44（高）/CD 24（低）表达可能是ESCC患者对FP-NAC耐药和预后不良的预测因子。
Background/Aim: Cancer stem cells (CSCs) contribute to resistance against neoadjuvant chemotherapy (NAC) in esophageal squamous cell carcinoma (ESCC). We conducted a retrospective observational study for the relationship between the expression levels of CSC markers in biopsy specimens prior to 5-fluorouracil plus cisplatin (FP)-NAC and the pathological responses. Patients and Methods: We included 171 patients with ESCC who underwent the FP-NAC followed by radical resection. Biopsy specimens prior to the FP-NAC were obtained and immunochemically stained for CD44, CD133, and CD24. Results: The biopsy specimens of the non-responders had the CD44(high)/CD24(low) expression at high levels, which was found as an independent predictor of not only FP-NAC resistance but also poor overall survival by multivariate analyses. Conclusion: CD44(high)/CD24(low) expression in the biopsy specimens prior to FP-NAC may be a predictor of FP-NAC resistance and poor prognosis of ESCC patients.