GENDER-RELATED DIFFERENCES IN REGIONAL CEREBRAL GLUCOSE-METABOLISM IN NORMAL VOLUNTEERS
GENDER-RELATED DIFFERENCES IN REGIONAL CEREBRAL GLUCOSE-METABOLISM IN NORMAL VOLUNTEERS
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DOI：
10.1016/0165-1781(94)90037-x
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发表时间：
1994-02-01
影响因子：
11.3
通讯作者：
COHEN, RM
中科院分区：
文献类型：
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作者：
ANDREASON, PJ;ZAMETKIN, AJ;COHEN, RM
正电子发射断层扫描研究表明，脑葡萄糖代谢率（CMRglu）的变化与抑郁、攻击性、冲动和多动症状相关。表现出这些症状的精神疾病在男女中所占比例不成比例。我们评估了对照组（21名男性和18名女性）区域CMRglu的性别差异，特别关注全球，眶额和左前外侧前额叶皮质（LAPFC）CMRglu。存在女性中总体CMRglu高于男性的趋势。区域CMRglu男性低于女性的眶额区。在LAPFC区域没有观察到任何差异。
Positron emission tomography studies have correlated changes in the cerebral metabolic rate of glucose utilization (CMRglu) with symptoms of depression, aggression, impulsivity, and hyperactivity. Psychiatric disorders in which these symptoms are manifested are disproportionately represented among the sexes. We evaluated gender differences in regional CMRglu in control subjects (21 men and 18 women) with particular interest in the global, orbital frontal, and left anterolateral prefrontal cortical (LAPFC) CMRglu. A trend was present for global CMRglu to be greater in women than in men. Regional CMRglu was lower in men than in women in the orbital frontal area. No differences were observed in the LAPFC region.