Cobalt-Catalyzed Umpolung Alkylation of Imines To Generate α-Branched Aliphatic Amines.
Cobalt-Catalyzed Umpolung Alkylation of Imines To Generate α-Branched Aliphatic Amines.
复制标题
钴催化亚胺的 Umpolung 烷基化生成α-支链脂肪胺。
DOI：
10.1021/acs.orglett.1c00835
复制
发表时间：
2021
期刊：
影响因子：
5.2
通讯作者：
Zhang Xia
中科院分区：
文献类型：
--
作者：
Wan Li-Qiang;Cao Jin-Ge;Niu Dawen;Zhang Xia
本文报道了一种由亚胺制备α-支链脂肪胺的通用温和方法。该方法利用钴催化的亚胺极性烷基化反应，采用易于获得的反应伙伴，并具有广泛的底物范围。机制研究表明，这种转化是通过自由基途径发生的。
Here we report a general and mild approach to prepare α-branched aliphatic amines from imines. This method capitalizes on a cobalt-catalyzed umpolung alkylation of imines, employs easily available reaction partners, and demonstrates a broad substrate scope. Mechanistic studies suggest this transformation occurs by a radical pathway.