Vulnerability to substance abuse and psychopathology among siblings of opioid abusers.
Vulnerability to substance abuse and psychopathology among siblings of opioid abusers.
复制标题
阿片类药物滥用者的兄弟姐妹易受药物滥用和精神病理学影响。
DOI：
10.1097/00005053-199203000-00002
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Rounsaville,BJ
中科院分区：
文献类型：
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作者：
Luthar,SS;Anton,SF;Merikangas,KR;Rounsaville,BJ
在201名阿片类药物成瘾先证者的兄弟姐妹中探索了药物滥用和精神病理学的脆弱性。根据476名兄弟姐妹的家族史对疾病进行了评估;还直接采访了133名兄弟姐妹的子集。结果表明：（a）阿片类成瘾者的兄弟姐妹中有几种精神疾病的发生率明显高于社区中的发生率;（B）与成瘾者的父母相比，兄弟姐妹中药物滥用和反社会人格的发生率较高;（c）存在严重精神疾病显著增加了兄弟姐妹中药物滥用的风险;和d）精神病理学似乎先于药物滥用在这个组中的发病年龄。在整个群体中复制了与兄弟姐妹的访谈样本获得的结果。研究结果进行了讨论的分类和治疗药物滥用的影响。
Vulnerability to drug abuse and psychopathology was explored among siblings of 201 opioid-addicted probands. Disorders were evaluated based on family histories among 476 siblings; a subset of 133 siblings was also directly interviewed. Results indicated that a) siblings of opiate addicts had substantially higher rates of several disorders in comparison with rates in the community; b) as compared with parents of addicts, siblings had elevated rates of substance abuse and antisocial personality; c) the presence of a major psychiatric disorder significantly increased the risk of developing substance abuse among siblings; and d) psychopathology appeared to precede drug abuse in terms of age of onset in this group. Results obtained with the interviewed sample of siblings were replicated in the overall group. Findings of the study are discussed in terms of implications for the classification and treatment of substance abuse.