Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study.
Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study.
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饮食中的胆碱摄入量是否与痴呆症和阿尔茨海默氏病有关？ Framingham心脏研究的结果。
DOI：
10.1093/ajcn/nqac193
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发表时间：
2022-11
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动物和人类研究均报告了胆碱与认知的正相关关系，但胆碱与人类患痴呆症或阿尔茨海默病 (AD) 风险的关系尚不清楚。我们的目的是检验以下假设：膳食胆碱摄入量较低或较高分别与痴呆症和 AD 风险增加或降低相关。使用来自弗雷明汉心脏研究后代队列考试 5 至考试 9 的数据。参与者均未患痴呆症和中风，并且在第 5 次考试中具有有效的自我报告的 126 项哈佛 FFQ。总胆碱、其贡献化合物和甜菜碱的摄入量是根据已发布的营养数据库估算的。每次考试的摄入量都会更新，以代表 5 次考试的累积平均摄入量。在混合效应 Cox 比例风险模型中检查膳食胆碱摄入量与痴呆和 AD 之间的关联，并调整协变量。共有 3224 名参与者（53.8% 为女性；平均±标准差年龄，54.5±9.7 岁）接受随访，平均±标准差为 16.1±5.1 岁（1991-2011 年）。共有 247 例痴呆症病例，其中 177 例为AD。膳食胆碱摄入量与痴呆和 AD 呈非线性关系。调整协变量后，低胆碱摄入量（痴呆和 AD 分别定义为 ≤ 219 和 ≤ 215 mg/d）与痴呆和 AD 发生显着相关。胆碱摄入量低与痴呆和 AD 的风险增加有关。
The positive association of choline for cognition has been reported in both animal and human studies, yet the associations of choline with the risks of incident dementia or Alzheimer's disease (AD) in humans is unclear. Our objective was to test the hypothesis that lower or higher dietary choline intake is associated with increased or decreased, respectively, risks of incident dementia and AD. Data from the Framingham Heart Study Offspring Cohort exam 5 to exam 9 were used. Participants were free of dementia and stroke, with a valid self-reported 126-item Harvard FFQ at exam 5. The intakes of total choline, its contributing compounds, and betaine were estimated based on a published nutrient database. The intakes were updated at each exam to represent the cumulative average intake across the 5 exams. The associations between dietary choline intakes and incident dementia and AD were examined in mixed-effect Cox proportional hazard models, adjusting for covariates. A total of 3224 participants (53.8% female; mean ± SD age, 54.5 ± 9.7 y) were followed up for a mean ± SD of 16.1 ± 5.1 y (1991–2011). There were 247 incident dementia cases, of which 177 were AD. Dietary choline intake showed nonlinear relationships with incident dementia and AD. After adjusting for covariates, low choline intake (defined as ≤ 219 and ≤ 215 mg/d for dementia and AD, respectively) was significantly associated with incident dementia and incident AD. Low choline intake was associated with increased risks of incident dementia and AD.