Quantification of vasa vasorum density in multi-slice computed tomographic coronary angiograms: role of computed tomographic image voxel size.
Quantification of vasa vasorum density in multi-slice computed tomographic coronary angiograms: role of computed tomographic image voxel size.
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DOI：
10.1097/rct.0b013e3181bb0d32
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发表时间：
2010-03
影响因子：
1.3
通讯作者：
Ritman EL
中科院分区：
文献类型：
--
作者：
Moritz R;Eaker DR;Langheinrich AC;Jorgensen SM;Bohle RM;Ritman EL
本研究的动机是使用CT检测早期冠状动脉粥样硬化的可能性增加的CT值在动脉壁血管增生造成的。对具有早期动脉粥样硬化变化的冠状动脉（n=5）注射Microfil®并扫描（micro-CT）。将噪声添加到扫描投影数据集（以表示当前临床CT扫描仪的辐射暴露），然后重建以生成不同体素大小的3D图像。如果体素尺寸小于（150μm）3，则由于血管中的造影剂而检测到较高的CT值。在大于（100μm）3的体素处，主腔中的造影剂显著增加了CT值，而在主腔中没有造影剂的相同标本的CT值保持不变。体素尺寸<（200μm）3需要定量由于血管增生引起的动脉壁混浊。
This study is motivated by the possibility of using CT to detect early coronary atherosclerosis by the increased CT-values within the arterial wall resulting from vasa vasorum proliferation. Coronary arteries (n=5) with early atherosclerotic changes were injected with Microfil® and scanned (micro-CT). Noise was added to the scan projection data sets (to represent the radiation exposure of current clinical CT-scanners), and then reconstructed to generate 3D-images at different voxel sizes. Higher CT-values were detected due to contrast agent in vasa vasorum if voxel size was less than (150μm)3. Contrast in the main lumen increased CT-values dramatically at voxels greater than (100μm)3, whereas CT-values of the same specimen without contrast in the main lumen remained constant. Voxel sizes < (200μm)3 are needed to quantitate arterial wall opacification due to vasa vasorum proliferation.