HL4-DPB1*0201 is associated with susceptibility to atopic myelitis in Japanese
HL4-DPB1*0201 is associated with susceptibility to atopic myelitis in Japanese
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DOI：
10.1016/j.jneuroim.2012.07.007
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发表时间：
2012-10-15
影响因子：
3.3
通讯作者：
Kira, Jun-ichi
中科院分区：
文献类型：
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作者：
Sato, Shinya;Isobe, Noriko;Kira, Jun-ichi
为了确定特应性脊髓炎 (AM) 易感性与人类白细胞抗原 (HLA)-DPB1 和 -DRB1 等位基因多态性之间的关系，我们比较了日本 55 名 AM 患者和 367 名无关健康对照之间的每种表型频率。 AM 患者中 HLA-DPB1*0201 等位基因的出现频率显着高于健康对照（54.5% vs. 31.9%，校正 P 值 = 0.0150，比值比 = 2.564，95% 置信区间 = 1.444-4.554）。我们的结果表明，AM 的免疫遗传学背景不同于其他中枢神经系统自身免疫性疾病，例如多发性硬化症和视神经脊髓炎，后者显示出独特的 HLA II 类关联。 (C) 2012 Elsevier B.V. 保留所有权利。
To determine the relationship between susceptibility to atopic myelitis (AM) and polymorphisms of the human leukocyte antigen (HLA)-DPB1 and -DRB1 alleles, we compared each phenotype frequency between 55 AM patients and 367 unrelated healthy controls in Japan. The HLA-DPB1*0201 allele was significantly more frequent in AM patients than in healthy controls (54.5% vs. 31.9%, corrected P value = 0.0150, odds ratio = 2.564, 95% confidence interval = 1.444-4.554). Our result suggests that the immunogenetic back-ground of AM differs from that of other CNS autoimmune diseases, such as multiple sclerosis and neuromyelitis optica, which show distinct HLA class II associations. (C) 2012 Elsevier B.V. All rights reserved.