Coordination of crosstalk between MAPK-PKC pathways: an exploratory study.
Coordination of crosstalk between MAPK-PKC pathways: an exploratory study.
复制标题
DOI：
10.1049/iet-syb:20050085
复制
发表时间：
2007-03
影响因子：
2.3
通讯作者：
S. Sreenath;R. Soebiyanto;M. Mesarovic;Olaf Wolkenhauer
中科院分区：
文献类型：
--
作者：
S. Sreenath;R. Soebiyanto;M. Mesarovic;Olaf Wolkenhauer
信号通路网络为细胞响应各种生物刺激提供了一个强大的机制。通过两个相互连接的途径-丝裂原活化蛋白激酶（MAPK）和蛋白激酶C （PKC）之间的组织原理的观点，证明了细胞适应。路径的多级系统表示用于确定有助于自适应行为和协调的路径组件。这种适应可以被认为是通过协调器参数的变化来表现的。在硅实验是使用文献中的MAPK-PKC数学模型进行的，该模型使用生物功能进行模块化。通过广泛的、有指导的参数化硅实验，PLA2子系统被证明是一个协调器。结果表明，协调器的不同参数不仅激活了通路网络，否则通路活性很低，而且还揭示了系统在没有输入的情况下激活自身的能力，表明了有界自治原理的相关性。
Networks of signaling pathways provide a robust mechanism for cells to respond to various biological stimuli. Cell adaptation through the viewpoint of an organising principle between two interconnected pathways--mitogen-activated protein kinase (MAPK) and protein kinase C (PKC) is demonstrated. A multilevel system representation of the pathways is used to determine the pathway components contributing to the adaptive behaviour and coordination. The adaptation can be thought of as being manifested by a change in parameters of the coordinator. In silico experiments are conducted using MAPK-PKC mathematical model in the literature, which is modularised using biological functionality. Through extensive, guided parametric in silico experiments, the PLA2 subsystem is shown to be a coordinator. Results show that varying parameters of the coordinator not only activate the network of pathways where otherwise the pathway activity is very low, but also reveal the ability of the system to activate itself in the absence of the input, indicating relevance of the principle of bounded autonomy.