Rheediinosides A and B, two antiproliferative and antioxidant triterpene saponins from Entada rheedii
Rheediinosides A and B, two antiproliferative and antioxidant triterpene saponins from Entada rheedii
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DOI：
10.1016/j.phytochem.2009.10.004
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发表时间：
2010-02-01
期刊：
影响因子：
3.8
通讯作者：
Tapondjou, Leon Azefack
中科院分区：
文献类型：
--
作者：
Nzowa, Laurence Kegah;Barboni, Luciano;Tapondjou, Leon Azefack
从 Entada rheedii 的种仁中分离出两种三萜皂苷。使用 1D- 和 2D-NMR 以及质谱法确定了它们的结构为 3-O-β-D-木吡喃糖基-(1 -> 3)-O-α-L-阿拉伯吡喃糖基-(1 -> 6)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖基酸 28-O-β-apiofuranosyl-(1 -> 3)-β-D-吡喃木糖基1-(1 -> 2)-β-D-吡喃葡萄糖苷（Rheediinoside A, 1）和 3-O-β-D-吡喃葡萄糖基-(1 -> 3)-O-[β-D-吡喃木糖基-(1 -> 3)-α-L-吡喃阿拉伯糖基-(1 -> 6)]-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖基酸28-O-β-apiofuranosyl-(1 -> 3)-beta-D-xylopyranosyl-(1 -> 2)-beta-D-glucopyranoside (Rheediinoside B, 2)。测试了化合物 1 和 2 对 T98G、A431、PC3 和 B16-F1 细胞系的抗增殖活性，并进一步测试了它们的抗氧化特性。这些化合物具有中等的细胞毒性和抗氧化特性，而大黄苷 B 在所有测定中都比大黄苷 A 更活跃。(C) 2009 Elsevier Ltd. 保留所有权利。
Two triterpenoid saponins have been isolated from the seed kernels of Entada rheedii. Their structures have been established using 1D- and 2D-NMR and mass spectrometry as 3-O-beta-D-xylopyranosyl-(1 -> 3)-O-alpha-L-arabinopyranosyl-(1 -> 6)-2-acetylamino-2-deoxy-beta-D-glucopyranosylentagenic acid 28-O-beta-apiofuranosyl-(1 -> 3)-beta-D-xylopyranosy1-(1 -> 2)-beta-D-glucopyranoside (Rheediinoside A, 1) and 3-O-beta-D-glucopyranosyl-(1 -> 3)-O-[beta-D-xylopyranosyl-(1 -> 3)-alpha-L-arabinopyranosyl-(1 -> 6)]-2-acetylamino-2-deoxy-beta-D-glucopyranosylentagenic acid 28-O-beta-apiofuranosyl-(1 -> 3)-beta-D-xylopyranosyl-(1 -> 2)-beta-D-glucopyranoside (Rheediinoside B, 2). Compounds 1 and 2 were tested for their antiproliferative activity against T98G, A431, PC3 and B16-F1 cell lines, and further for their antioxidant properties. Moderate cytotoxic potency and antioxidant properties were found for these compounds whereas Rheediinoside B was in all assays more active than Rheedimoside A. (C) 2009 Elsevier Ltd. All rights reserved.