Regulatory mechanisms of mechanotransduction in genome instability
Regulatory mechanisms of mechanotransduction in genome instability
复制标题
DOI：
10.1007/s42764-022-00086-x
复制
发表时间：
2022-10
期刊：
影响因子：
--
通讯作者：
Lijun Zheng;Mintao Ji;H. Zhang;L. Chang
中科院分区：
文献类型：
--
作者：
Lijun Zheng;Mintao Ji;H. Zhang;L. Chang
在个体发育和成人体内平衡过程中，机械力为细胞提供重要的信号，指导细胞和组织的行为。此外，细胞通过机械转导接收和传递机械信号，控制细胞增殖、分化和死亡。机械微环境和细胞内部机械系统的失调可导致包括肿瘤在内的多种疾病。同时，基因组的不稳定性是癌症发生和发展的关键步骤之一。尽管大量的实验表明细胞力学和基因组不稳定性之间存在联系，但潜在的机制尚不清楚。在这里，我们讨论了细胞外机械微环境、机械传感受体、细胞骨架系统和核机械转导的机械信号如何影响基因组的不稳定性。
During ontogeny and adult homeostasis, mechanical forces provide cells with important signals that guide cellular and tissue behavior. In addition, cells receive and transmit mechanical signals through mechanotransduction that control cell proliferation, differentiation, and death. Dysregulation of the mechanical microenvironment and the internal mechanical system of cells can lead to a variety of diseases, including tumors. Meanwhile, genomic instability is one of the key steps in cancer initiation and progression. Although numerous experiments have suggested a link between cellular mechanics and genome instability, the underlying mechanisms are unclear. Here, we discuss how the extracellular mechanical microenvironment, mechanosensing receptors, cytoskeletal systems, and mechanosignaling of nuclear mechanotransduction affect genomic instability.