Dopamine receptor manipulation does not alter patterns of partner preference in long-term marmoset pairs.
Dopamine receptor manipulation does not alter patterns of partner preference in long-term marmoset pairs.
复制标题
多巴胺受体操纵不会改变长期狨猴配对中的伴侣偏好模式。
DOI：
10.1016/j.physbeh.2019.03.004
复制
发表时间：
2019
影响因子：
2.9
通讯作者：
French,JeffreyA
中科院分区：
文献类型：
--
作者：
Carp,SarahB;Taylor,JackH;French,JeffreyA
社会上的一夫一妻制伴侣之间的关系是动态的，并受到神经生物学影响的调节。在啮齿动物模型中的研究表明，神经递质多巴胺(DA)及其受体(DAR)在调节一夫一妻键的形成和维持中起着关键作用。DAR的激活是在长期配对的绒猴身上进行药理学操作的。暴露在DAR操作下的绒猴在两种社交条件下进行了伴侣偏好测试：一种是它们的配偶可以视觉观察到它们与异性个体的互动，另一种是它们的伴侣无法视觉观察到这些互动。与不熟悉的同种相比，绒猴表现出对配偶的空间偏好，然而，它们对不熟悉的同种比它们的配偶表现出性偏好。D1R操作对绒猴的伴侣偏好没有影响。然而，D2Rs的激活减少了绒猴与刺激动物接触的时间，表明社会兴趣减少了，但并没有减少与刺激动物接触的时间或性引诱的数量。此外，社会环境(配偶的能见度)不影响绒猴的行为。这些发现表明，D2Rs可能参与调节绒猴的一般社会兴趣，但不是特定于伴侣的社会兴趣。
The relationship between socially monogamous mates is dynamic and regulated by neurobiological influences. Research in rodent models has indicated a key role for the neurotransmitter dopamine (DA) and its receptors (DAR) in mediating the formation and maintenance of monogamous bonds. DAR activation was pharmacologically manipulated in marmosets housed in long-term pairs. Marmosets exposed to DAR manipulation were tested in a partner preference test under two social conditions: one in which their mate could visually observe their interactions with an opposite-sex individual, and one in which their pair mate could not visually observe these interactions. Marmosets displayed a spatial preference for the mate compared to an unfamiliar conspecific, however, they displayed a sexual preference for an unfamiliar conspecific over their mate. D1R manipulation had no impact on marmoset partner preference. However, activation of D2Rs reduced the time marmosets spent in contact with either stimulus animal, indicating a decrease in social interest, but did not reduce time spent in proximity to the stimulus animals nor number of sexual solicitations. Additionally, social context (visibility of the mate) did not influence marmoset behavior. These findings suggest that D2Rs may be involved in regulating generalized, but not partner-specific, social interest in marmoset monkeys.