The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region.
The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region.
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发表时间：
1988-11
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通讯作者：
R. Soininen;M. Huotari;S. L. Hostikka;D. J. Prockop;Karl Tryggvason
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作者：
R. Soininen;M. Huotari;S. L. Hostikka;D. J. Prockop;Karl Tryggvason
具有小基因组的简单生物体的许多基因在相反的 DNA 链上编码，因此基因要么重叠，要么一个基因嵌套在另一个基因内（Normark, S.、Bergström, S.、Edlund, T.、Grundström, T.、Jaurin, B.、Lindberg, F.P. 和 Olsson, D. (1983) Annu. Rev. Genet. 17, 499-525；Chen, C.、Malone, T.、Beckendorf, S.K. 和 Davis, R.L. Nature (1987) 329, 721-724）。相比之下，复杂生物体的大多数基因分散在基因组中相距很远的位置。在这里，我们报告说，人类 IV 型胶原蛋白的 α 1 和 α 2 链的基因编码在来自基因座的相反 DNA 链上，这些基因座位置非常接近，以至于它们之间的距离可能只有 42 个碱基对。这些结果首次描述了来自复杂生物体的两个结构基因，它们编码同一蛋白质分子的两条多肽链，但具有重叠的 5' 侧翼区域。
Many of the genes of simple organisms with small genomes are encoded on opposite DNA strands so that the genes either overlap or one gene is nested within another gene (Normark, S., Bergström, S., Edlund, T., Grundström, T., Jaurin, B., Lindberg, F.P., and Olsson, D. (1983) Annu. Rev. Genet. 17, 499-525; Chen, C., Malone, T., Beckendorf, S.K., and Davis, R.L. Nature (1987) 329, 721-724). In contrast, most of the genes of complex organisms are dispersed in the genome in widely separated locations. Here, we report that the genes for the alpha 1 and alpha 2 chains of human type IV collagen are encoded on opposite DNA strands from loci that are so closely located that they may be separated by as little as 42 base pairs. The results provide the first description of two structural genes from a complex organism that code for two polypeptide chains of the same protein molecule but have overlapping 5'-flanking regions.