Plastoquinones from Sargassum yezoense; Chemical Structures and Effects on the Activation of Peroxisome Proliferator-Activated Receptor Gamma
Plastoquinones from Sargassum yezoense; Chemical Structures and Effects on the Activation of Peroxisome Proliferator-Activated Receptor Gamma
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DOI：
10.1248/cpb.59.834
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发表时间：
2011-07-01
影响因子：
1.7
通讯作者：
Um, Byung Hun
中科院分区：
文献类型：
--
作者：
Kim, Min Cheol;Kwon, Hak Cheol;Um, Byung Hun
从韩国东海岸采集的褐藻马尾藻中分离出四种新的质体醌以及两种已知化合物：马尾藻氢奎宁酸和马尾藻奎宁酸。这些化合物的结构通过核磁共振和质谱等光谱分析得到阐明。它们的结构被命名为间萜酚 A (1)、B (2)、C (3) 和 D (4)，其特征在于具有氧化二萜酸链的 6-甲基-1,4-苯并氢醌部分。 Meroterphens A-D 对过氧化物酶体增殖物激活受体 γ (PPAR γ) 显示出有效的激活作用。
Four new plastoquinones, together with two known compounds, sargahydroquinoic acid and sargaquinoic acid, were isolated from the brown alga, Sargassum yezoense collected from the eastern coast of Korea. The structures of these compounds were elucidated based on spectroscopic analyses including NMR and MS. Their structures designated as meroterphenol A (1), B (2), C (3) and D (4) were characterized by a 6-methyl-1,4-benzohydroquinone moiety with an oxygenated diterpenoic acid chain. Meroterphenols A-D showed potent activation effects on peroxisome proliferator-activated receptor gamma (PPAR gamma).