An Avian Basal Ganglia-Forebrain Circuit Contributes Differentially to Syllable Versus Sequence Variability of Adult Bengalese Finch Song
An Avian Basal Ganglia-Forebrain Circuit Contributes Differentially to Syllable Versus Sequence Variability of Adult Bengalese Finch Song
复制标题
DOI：
10.1152/jn.91089.2008
复制
发表时间：
2009-06-01
影响因子：
2.5
通讯作者：
Brainard, Michael S.
中科院分区：
文献类型：
--
作者：
Hampton, Cara M.;Sakata, Jon T.;Brainard, Michael S.
Hampton CM, Sakata JT, Brainard MS.鸟类基底神经节-前脑回路对成年孟加拉雀鸣叫的音节和序列变异的不同贡献。中国生物医学工程学报（英文版），2009。首次发表于2009年4月8日；doi: 10.1152 / jn.91089.2008。行为变异性对运动技能的学习很重要，但即使在学习良好的行为中也会持续存在并受到积极调节。在成年鸣禽中，两种类型的歌声变异性可以持续存在，并受到社会环境的调节：音节结构的变异性和音节顺序的变异性。这两种类型的成人变异性的控制在多大程度上是共同的还是不同的仍然未知。基底神经节-前脑回路LMAN（前乳头外侧大细胞核）的输出与歌曲变异性有关。例如，在成年斑胸草雀中，LMAN神经元主动控制音节结构的变异性。然而，尚不清楚LMAN是否会导致成年斑马雀音节序列的变化，因为成年斑马雀鸣叫的序列变化很小。相比之下，孟加拉雀在成年后的音节结构和音节顺序上都保持着可变性。我们分析了LMAN损伤对成年孟加拉雀音节结构和序列变异以及这些变异形式的社会调节的影响。我们发现LMAN病变显著降低了音节结构的可变性，而不是音节序列的可变性。我们还发现LMAN病变消除了音节结构变异性的社会调节，但对序列变异性的调节没有显著影响。这些结果表明LMAN对成人歌曲的音节和序列变异有不同的贡献，并表明这些形式的变异是由不同的神经通路调节的。
Hampton CM, Sakata JT, Brainard MS. An avian basal ganglia-forebrain circuit contributes differentially to syllable versus sequence variability of adult Bengalese finch song. J Neurophysiol 101: 3235-3245, 2009. First published April 8, 2009; doi:10.1152/jn.91089.2008. Behavioral variability is important for motor skill learning but continues to be present and actively regulated even in well-learned behaviors. In adult songbirds, two types of song variability can persist and are modulated by social context: variability in syllable structure and variability in syllable sequencing. The degree to which the control of both types of adult variability is shared or distinct remains unknown. The output of a basal ganglia-forebrain circuit, LMAN (the lateral magnocellular nucleus of the anterior nidopallium), has been implicated in song variability. For example, in adult zebra finches, neurons in LMAN actively control the variability of syllable structure. It is unclear, however, whether LMAN contributes to variability in adult syllable sequencing because sequence variability in adult zebra finch song is minimal. In contrast, Bengalese finches retain variability in both syllable structure and syllable sequencing into adulthood. We analyzed the effects of LMAN lesions on the variability of syllable structure and sequencing and on the social modulation of these forms of variability in adult Bengalese finches. We found that lesions of LMAN significantly reduced the variability of syllable structure but not of syllable sequencing. We also found that LMAN lesions eliminated the social modulation of the variability of syllable structure but did not detect significant effects on the modulation of sequence variability. These results show that LMAN contributes differentially to syllable versus sequence variability of adult song and suggest that these forms of variability are regulated by distinct neural pathways.