Mismatch responses related to temporal discrimination of somatosensory stimulation
Mismatch responses related to temporal discrimination of somatosensory stimulation
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DOI：
10.1016/j.clinph.2005.04.021
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发表时间：
2005-08-01
影响因子：
4.7
通讯作者：
Kakigi, R
中科院分区：
文献类型：
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作者：
Akatsuka, K;Wasaka, T;Kakigi, R
目的：确定预注意诱发的体感失配负性成分的存在，并研究该成分在客观临床诊断中的应用。方法：首先，我们确定每个受试者成对刺激的时间辨别阈值（DT），并向手部施加两个顺序的电刺激，成对刺激时间为（1）DT ~ 10 ms，（2）DT-30 ms和（3）DT +50 ms。然后，我们使用一种古怪的范式，频繁（标准）和罕见（偏差）记录ERPs。在第一个实验中，我们使用DT-30 ms和DT-10 ms两种刺激，在第二个实验中，我们使用DT-30 ms和DT +50 ms两种刺激。在每个实验中，识别出两个特定的分量，一个在大约60 ms处达到峰值的负分量（N60）和一个在大约100-200 ms处达到峰值的大的正分量（P150），主要是在偏离刺激之后，被认为是躯体感觉不匹配的成分。结论：N60可能产生于被试能够清晰辨别的任务中，而P150可能产生于被试需要精细辨别的任务中，它似乎对应于听觉失配负波。意义：我们证实了我们的新方法可以用于时间辨别的客观检测。(c)2005年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To determine the existence of a preattentively evoked somatosensory mismatch negativity component and to investigate the use of that component in objective clinical diagnostics.Methods: First we determined the temporal discrimination threshold (DT) of paired stimuli in each subject, and applied two sequential electrical stimuli to the hand with paired stimulus times of (1) DT -10 ms, (2) DT -30 ms and (3) DT +50 ms. Then, we recorded ERPs using an oddball paradigm, frequent (standard) and rare (deviant). We used two stimuli, DT-30 ms and DT-10 ms, in the first experiment, and DT -30 ms and DT +50 ms, in the second experiment.Results: In each experiment, two specific components, a negative component peaking at approximately 60 ms (N60) and a large positive component peaking around 100-200 ms (P150), were identified, mainly following the deviant stimulus, which were considered somatosensory mismatch components. N60 was more remarkably identified in the second experiment and P150 in the first.Conclusions: N60 might be generated during tasks which subjects can clearly discriminate, but P150, which seems to correspond to auditory mismatch negativity, might be generated in tasks which require fine discrimination.Significance: We confirmed that our new method could be used for the objective examination of temporal discrimination. (c) 2005 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.