SYNERGISM BETWEEN AFLATOXIN AND OCHRATOXIN-A IN BROILER-CHICKENS
SYNERGISM BETWEEN AFLATOXIN AND OCHRATOXIN-A IN BROILER-CHICKENS
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DOI：
10.3382/ps.0600550
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发表时间：
1981-01-01
期刊：
影响因子：
4.4
通讯作者：
DOERR, JA
中科院分区：
文献类型：
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作者：
HUFF, WE;DOERR, JA
一个2倍。使用由4个处理（0、2.5 μ g/g黄曲霉毒素、2.0 μ g/g赭曲霉毒素A和2.5 μ g/g黄曲霉毒素+2.0 μ g/g赭曲霉毒素A）组成的2析因实验设计，每个重复10只鸟，6个重复，以评价黄曲霉毒素和赭曲霉毒素A之间的协同作用。小鸡（Hubbard）Hubbard）从孵化开始一直维持这些饮食处理，直到它们达到3周龄，此时实验终止。肝、脾、胰腺和腺胃的大小受毒素影响显著（P <0.05）。未观察到对这些器官大小的协同效应。肾脏和砂囊对同时暴露于这些真菌毒素敏感，并显著增大（P <0.05）。肾脏是黄曲霉毒素和赭曲霉毒素A联合毒性最敏感的器官，肾病是这种相互作用的最重要特征。黄曲霉毒素和赭曲霉毒素A之间的协同作用显著（P <0.05）降低了生长速率，并在数值上增加了死亡率，表明共污染饲料的毒性增强。黄曲霉毒素显著升高肝脏脂质水平（P <0.05），赭曲霉毒素A显著降低肝脏脂质水平（P <0.05）.两种真菌毒素对该参数的相互作用是显著的（P <0.05），并且联合作用表明赭曲霉毒素A抑制黄曲霉毒素正常诱导的脂质积累。毒性增强协同作用存在于真菌毒素和症状模式之间，在多种真菌中毒中改变。肾病是这种相互作用的主要效应，具有诊断重要性。
A 2 .times. 2 factorial experimental design consisting of 4 treatments (0, 2.5 .mu.g/g aflatoxin, 2.0 .mu.g/g ochratoxin A and 2.5 .mu.g/g aflatoxin + 2.0 .mu.g/g ochratoxin A) with 6 replicates of 10 birds each was used to evaluate the synergism between aflatoxin and ochratoxin A. The chicks (Hubbard .times. Hubbard) were maintained on these dietary treatments from hatching until they reached 3 wk of age, when the experiment was terminated. The size of the liver, spleen pancreas and proventriculus was significantly (P < 05) altered by the individual toxins. A synergistic effect on the size of these organs was not observed. The kidney and gizzard were sensitive to the coincident exposure to these mycotoxins and were significantly (P < .05) enlarged. The kidney was the most sensitive organ to the combined toxicity of aflatoxin and ochratoxin A and nephropathy was the most important characteristic of this interaction. The synergism between aflatoxin and ochratoxin A significantly (P < .05) decreased growth rate and numerically increased mortality, demonstrating the enhanced toxicity of cocontaminated feed. Liver lipid levels were significantly (P < .05) increased by aflatoxin and decreased by ochratoxin A. The interaction of both mycotoxins on this parameter was significant (P < .05) and the combined effect demonstrated that ochratoxin A inhibited lipid accumulation normally induced by aflatoxin. Toxicity-enhancing synergisms existed between mycotoxins and symptom patterns were altered during multiple mycotoxicoses. Nephropathy was the primary effect of this interaction and of diagnostic importance.