Highly stable, ligand-clustered "patchy" micelle nanocarriers for systemic tumor targeting.
Highly stable, ligand-clustered "patchy" micelle nanocarriers for systemic tumor targeting.
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DOI：
10.1016/j.nano.2010.07.008
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发表时间：
2011-04
影响因子：
5.4
通讯作者：
Hammond, Paula T.
中科院分区：
文献类型：
--
作者：
Poon, Zhiyong;Lee, Jung Ah;Huang, Shenwen;Prevost, Richard J.;Hammond, Paula T.
合成了一种新型的线性-枝晶嵌段共聚物，并对其靶向递送性能进行了评价。在这种结构中，树突作为胶束外部块的使用允许在簇中呈现相对少量的配体，以增强靶向性，从而保持这些“斑块”胶束的长循环时间。多肽线性疏水块驱动胶束的形成，携带核负载药物，其独特的设计使其在体内具有极高的稳定性。我们发现，与非靶向载体相比，这些系统导致肿瘤中积累增加的时间延长（长达5天）。我们还证明，在靶向纳米颗粒系统中递送紫杉醇的功效增加了4倍，同时显着降低了化疗的体内毒性。
A novel linear-dendritic block copolymer has been synthesized and evaluated for targeted delivery. The use of the dendron as the micellar exterior block in this architecture allows the presentation of a relatively small quantity of ligands in clusters for enhanced targeting, thus maintaining a long circulation time of these “patchy” micelles. The polypeptide linear hydrophobic block drives formation of micelles that carry core-loaded drugs, and their unique design gives them an extremely high level of stability in vivo. We have found that these systems lead to extended time periods of increased accumulation in the tumor (up to 5 days) compared to non-targeted vehicles. We also demonstrate a 4x increase in efficacy of paclitaxel when delivered in the targeted nanoparticle systems, while significantly decreasing in vivo toxicity of the chemotherapy treatment.
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影响因子：
4.9
作者：
Alexis F;Pridgen E;Molnar LK;Farokhzad OC
通讯作者：
Farokhzad OC
影响因子：
11.2
作者：
Kukowska-Latallo, JF;Candido, KA;Baker, JR
通讯作者：
Baker, JR
影响因子：
11.5
作者：
Kim, TY;Kim, DW;Bang, YJ
通讯作者：
Bang, YJ
影响因子：
5.8
作者：
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通讯作者：
Hunter, WL
影响因子：
3.5
作者：
McNeeley, Kathleen M.;Annapragada, Ananth;Bellamkonda, Ravi V.
通讯作者：
Bellamkonda, Ravi V.