WIDESPREAD SILENT TRANSMISSION OF PERTUSSIS IN FAMILIES - ANTIBODY CORRELATES OF INFECTION AND SYMPTOMATOLOGY
WIDESPREAD SILENT TRANSMISSION OF PERTUSSIS IN FAMILIES - ANTIBODY CORRELATES OF INFECTION AND SYMPTOMATOLOGY
复制标题
DOI：
10.1093/infdis/161.3.480
复制
发表时间：
1990-03-01
影响因子：
6.4
通讯作者：
CLARK, JL
中科院分区：
文献类型：
--
作者：
LONG, SS;WELKON, CJ;CLARK, JL
4名百日咳患儿及其18名家庭成员进行了为期1年的研究，以检测百日咳杆菌的感染和抗体反应。接触者百日咳感染发病率为83%。这些免疫接触者中三分之二的病例为亚临床病例。所有受感染的家庭接触者在索引病例被诊断时百日咳血清学试验诊断升高。文化确定只有20%的感染接触者。感染者平均有5.5的10个抗体测试诊断最近的感染。血清和鼻分泌物中百日咳毒素IgG的ELISA测定和丝状血凝素伊加的测定是最具鉴别力的诊断试验。指标病例和免疫接触者的抗体应答类型和时间不同，使得单次检测或采样无法识别所有感染者。症状性感染的特点是百日咳毒素抗体反应的幅度较高，无症状感染的丝状血凝素。百日咳免疫后，对疾病的免疫力大于对感染的保护。
Four children with pertussis and theirs 18 family members were subjects of a 1-year study to detect infection and antibody responses to Bordetella pertussis. Attack rate for pertussis infection in contacts was 83%. Two-thirds of cases in these immunized contacts were subclinical. All infected family contacts had diagnostically elevated serologic tests for pertussis at the time the index case was diagnosed. Culture identified only 20% of infected contacts. Infected individuals had a mean of 5.5 of 10 antibody tests diagnostic for recent infection. ELISA assay for IgG to pertussis toxin and assay for IgA to filamentous hemagglutinin on serum and nasal secretions were the most discriminating diagnostic tests. Indexes cases and immunized contacts had different type and timing of antibody responses, making a single assay or sampling unable to identify all infected individuals. Symptomatic infection was characterized by higher magnitude of pertussis toxin antibody response and asymptomatic infection by filamentous hemagglutinin. After pertussis immunization, immunity to disease is greater than is protection from infection.