Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions.
Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions.
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血红素加氧酶-1信号和生理病理条件下的氧化还原稳态。
DOI：
10.3390/biom11040589
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发表时间：
2021-04-16
期刊：
影响因子：
5.5
通讯作者：
Vanella L
中科院分区：
文献类型：
--
作者：
Consoli V;Sorrenti V;Grosso S;Vanella L
血红素加氧酶是负责降解内源性铁原卟啉血红素的酶；它催化反应的限速步骤，导致一氧化碳 (CO)、亚铁离子和胆绿素 (BV) 的释放，随后被胆绿素还原酶还原为胆红素 (BR)。几项研究引起了人们对 HO-1（酶诱导亚型）的有争议的作用的关注，指出了它在癌症和其他疾病发展中的影响，但也强调了其抗氧化活性的重要性。 HO-1 在氧化还原稳态中的贡献导致细胞氧化损伤的相关减少，这可以重新归因于其细胞保护作用，以及涉及 TIGAR（TP53 诱导的糖酵解和凋亡调节剂）等基因的其他内源性机制，而且还可以促进血红素主要转化产物的治疗功能，特别是一氧化碳 (CO)，它已被证明对 GSH 水平的实施有效，维持人体对氧化应激的抗氧化反应。本综述的目的是从文献中收集有关HO-1的大部分知识，从不同的角度进行分析，试图提出一个假设，揭示未知的HO-1参与途径，从而有助于促进新的治疗策略的发展，并为进一步研究以充分了解这一重要的抗氧化系统奠定基础。
Heme-oxygenase is the enzyme responsible for degradation of endogenous iron protoporphyirin heme; it catalyzes the reaction’s rate-limiting step, resulting in the release of carbon monoxide (CO), ferrous ions, and biliverdin (BV), which is successively reduced in bilirubin (BR) by biliverdin reductase. Several studies have drawn attention to the controversial role of HO-1, the enzyme inducible isoform, pointing out its implications in cancer and other diseases development, but also underlining the importance of its antioxidant activity. The contribution of HO-1 in redox homeostasis leads to a relevant decrease in cells oxidative damage, which can be reconducted to its cytoprotective effects explicated alongside other endogenous mechanisms involving genes like TIGAR (TP53-induced glycolysis and apoptosis regulator), but also to the therapeutic functions of heme main transformation products, especially carbon monoxide (CO), which has been shown to be effective on GSH levels implementation sustaining body’s antioxidant response to oxidative stress. The aim of this review was to collect most of the knowledge on HO-1 from literature, analyzing different perspectives to try and put forward a hypothesis on revealing yet unknown HO-1-involved pathways that could be useful to promote development of new therapeutical strategies, and lay the foundation for further investigation to fully understand this important antioxidant system.
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DOI：
10.1126/science.1211485
发表时间：
2011-12-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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发表时间：
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期刊：
PHARMACOLOGY & TOXICOLOGY
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通讯作者：
Miró, O
影响因子：
19.6
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影响因子：
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DOI：
10.1016/j.biocel.2006.03.013
发表时间：
2006-01-01
影响因子：
4
作者：
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通讯作者：
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