Pulsatile flow in the human left coronary artery bifurcation: Average conditions
Pulsatile flow in the human left coronary artery bifurcation: Average conditions
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DOI：
10.1115/1.2795948
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发表时间：
1996-02-01
影响因子：
1.7
通讯作者：
Ku, DN
中科院分区：
文献类型：
--
作者：
He, XJ;Ku, DN
冠状动脉中动脉粥样硬化的定位可由局部血流动力学特征决定。在这项研究中，脉动血流动力学的左冠状动脉分叉的数值模拟使用的频谱元素的方法，在现实的解剖和生理条件下。发现左前降支和回旋支冠状动脉的速度曲线都是偏斜的。速度偏斜产生的分叉，以及从弯曲的动脉在心肌表面。动脉壁剪切应力在分叉区域（包括侧壁）显著较低。最大的振荡行为局限于旋动脉的外壁。在左冠状动脉系统中，时间平均的平均壁面剪应力在3 - 98达因/厘米（2）之间变化。低切应力和振荡切应力沿着壁的高度局部化分布与人左冠状动脉粥样硬化的病灶位置密切相关。
The localization of atherosclerosis in the coronary arteries may be governed by local hemodynamic features. In this study, the pulsatile hemodynamics of the left coronary artery bifurcation was numerically simulated using the spectral element method for realistic in vivo anatomic and physiologic conditions. The velocity profiles were found to be skewed in both the left anterior descending and the circumflex coronary arteries. Velocity skewing arose from the bifurcation as well as from the curvature of the artery over the myocardial surface. Arterial wall shear stress was significantly lower in the bifurcation region, including the side walls. The greatest oscillatory behavior was localized to the outer wall of the circumflex artery. The time-averaged mean wall shear stress varied from about 3 to 98 dynes/cm(2) in the left coronary artery system. The highly localized distribution of low and oscillatory shear stress along the walls strongly correlates with the focal locations of atheroma in the human left coronary artery.