Study on effective extraction of chicken feather keratins and their films for controlling drug release.
Study on effective extraction of chicken feather keratins and their films for controlling drug release.
复制标题
DOI：
10.1039/c3bm00158j
复制
发表时间：
2013-04
影响因子：
6.6
通讯作者：
Xiaochun Yin;Fang-Ying Li;Yufeng He;Yan Wang;Rongmin Wang
中科院分区：
文献类型：
--
作者：
Xiaochun Yin;Fang-Ying Li;Yufeng He;Yan Wang;Rongmin Wang
我们报道了利用角蛋白制备具有孔隙率的角蛋白薄膜，用于受控药物输送系统。羽毛是目前家禽养殖业的一种重要废弃物，但由于羽绒制品不能有效地提取和利用，造成了环境问题。本文采用高效提取羽毛角蛋白的方法对羽毛角蛋白进行了提取。纯角蛋白的产率可达90%以上。其相对分子质量为20 kDa，分散性较低。用一种简单的方法制备了以提取的角蛋白为基础的薄膜，并显示了良好的力学性能。此外，还将羽毛角蛋白薄膜用于载药和释药。所制得的羽毛角蛋白生物聚合物膜具有pH响应性，并且具有可控的药物释放行为。综上所述，我们实现了一种简单的回收利用废弃羽毛的方法。它在生物医学领域的应用可能是一个有吸引力的候选者。
We report the fabrication of keratin films with porosity using keratin, for controlled drug delivery systems. Feathers are currently an important waste product from the poultry industry, however abandoned down products cause an environmentally difficult disposal problem as they are not efficiently extracted and applied. In this paper, feather keratin was extracted using a high-efficiency method. The yield of pure keratin was up to 90%. Its molecular weight was 20 kDa with low dispersity. The films, based on the extracted keratin, were prepared using a simple method, and showed good mechanical properties. Furthermore, the feather keratin films were used to load and release drugs. The resultant feather keratin biopolymer films were pH-responsive and showed controllable drug-release behavior. In summary, we achieved a simple method to reutilize disused feathers. It could be an attractive candidate for applications in the biomedical field.