Alpha‐fetoprotein production by hepatocellular carcinoma is prognostic of poor patients survival
Alpha‐fetoprotein production by hepatocellular carcinoma is prognostic of poor patients survival
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肝细胞癌产生的甲胎蛋白是患者生存不良的预后
DOI：
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发表时间：
1992
影响因子：
2.5
通讯作者：
Itsuo Miyazaki
中科院分区：
文献类型：
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作者：
R. Izumi;Kohichi Shimizu;M. Kiriyama;T. Hashimoto;M. Urade;M. Yagi;Y. Mizukami;A. Nonomura;Itsuo Miyazaki
采用抗生物素蛋白生物素过氧化物酶复合物免疫组织化学方法研究手术获得的肝细胞癌（HCC）组织标本中甲胎蛋白（AFP）的产生。观察AFP染色与血清AFP水平及病理结果的关系。我们研究了接受根治性肝切除术的HCC患者肿瘤中AFP染色的预后。AFP阳性患者血清AFP水平明显高于AFP阴性患者。AFP阳性与肿瘤大小、肿瘤包膜、血管浸润程度、肿瘤组织分化程度无明显关系。AFP阳性癌患者的预后比AFP阴性癌患者差（AFP阳性组和阴性组的5年生存率分别为26.7%和56.5%）。© 1992 Wiley利斯公司
Immunohistochemistry using the avidinbiotinperoxidase complex method was performed to study the production of alphafetoprotein (AFP) in hepatocellular carcinoma (HCC) tissue specimens which were obtained surgically. The relationship between staining for AFP and serum AFP levels or pathological findings was examined. The prognosis of the patients with HCC who underwent curative hepatic resections was studied with respect to the staining for AFP in their tumors. The mean serum AFP level in patients with positive AFP staining was significantly higher than in those with negative AFP staining. No significant relationship was found between AFP positivity and tumor size, tumor encapsulation, degree of vascular invasion, or the histological differentiation grade of the tumor. The patients with AFP‐positive carcinomas had a poorer prognosis than did those with AFP‐negative carcinomas (5‐year survival rate of AFP‐positive and negative groups were 26.7% and 56.5%, respectively). © 1992 Wiley‐Liss, Inc.