Pheochromocytoma and paraganglioma: An emerging cause of secondary osteoporosis
Pheochromocytoma and paraganglioma: An emerging cause of secondary osteoporosis
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嗜铬细胞瘤和副神经节瘤：继发性骨质疏松症的新病因
DOI：
10.1016/j.bone.2020.115221
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发表时间：
2020
期刊：
影响因子：
4.1
通讯作者：
Ogawa Y; Q-AND-A study group
中科院分区：
文献类型：
--
作者：
Yokomoto-Umakoshi M;Umakoshi H;Fukumoto T;Matsuda Y;Nagata H;Ogata M;Kawate H;Miyazawa T;Sakamoto R;Ogawa Y; Q-AND-A study group
嗜铬细胞瘤（PHEO）和副神经节瘤（PGL）（PHEO和PGL：PPGL）是产生儿茶酚胺的神经内分泌肿瘤，已知与低骨密度（BMD）相关。然而，目前尚不清楚PPGL是否与骨质疏松性骨折的高患病率相关，如果是的话，手术切除是否能改善BMD已经得到解决。1）对49例PPGL患者和61例无功能性AT患者进行脊柱X线平片检查，2）对23例PPGL患者进行骨密度检查。2)在PPGLs，骨密度进行了评估，在基线和surgical.ResultsPPGLs有较高的患病率VF（43% [21/49]）比非功能性AT（16% [10/61];P= 0.002）。校正年龄和性别后，PPGL与VF相关（比值比，4.47; 95%置信区间，1.76-11.3;p= 0.001）。在PPGLs，在腰椎骨密度得到改善（前：0.855 ± 0.198 g/cm 2，后：0.888 ± 0.169 g/cm 2，平均差异：0.032 g/cm 2，p= 0.026），与3.8%increases.ConclusionThis研究表明，PPGLs与VF和他们的手术切除有助于骨小梁的骨密度的改善。这些观察结果支持PPGL是继发性骨质疏松症的一种新兴原因的观点。
ContextPheochromocytoma (PHEO) and paraganglioma (PGL) (PHEO and PGL: PPGLs) are catecholamine-producing neuroendocrine tumors, which are known to be associated with low bone mineral density (BMD). However, it remains unknown whether PPGLs are associated with high prevalence of osteoporotic fracture and if so, whether their surgical resection improves BMD has been addressed.ObjectiveTo evaluate the risk of vertebral fracture (VF) in PPGLs and the improvement of BMD after surgery.Design and settingsA retrospective cross-sectional study in a single referral center.ParticipantsThis study included the following patients: 1) 49 patients with PPGLs and 61 patients with non-functional AT who were examined radiograph of the spine, 2) 23 patients with PPGLs who were examined BMD at follow-up.Intervention1) The prevalence of VF was evaluated between PPGLs and non-functional AT. 2) In PPGLs, BMD was evaluated at baseline and after surgery.ResultsPPGLs had a higher prevalence of VF (43% [21/49]) than non-functional AT (16% [10/61];p= 0.002). PPGLs were associated with VF after adjusting for age and sex (odds ratio, 4.47; 95% confidence interval, 1.76–11.3;p= 0.001). In PPGLs, BMD at the lumber spine was improved (before: 0.855 ± 0.198 g/cm2, after: 0.888 ± 0.169 g/cm2, mean of the difference: 0.032 g/cm2,p= 0.026), with 3.8% increase.ConclusionThis study demonstrates that PPGLs was associated with VF and that their surgical resection contributes to the improvement of BMD in the trabecular bone. These observations support the notion that PPGLs are an emerging cause of secondary osteoporosis.