Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders
Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders
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DOI：
10.1182/blood.v87.10.4296.bloodjournal87104296
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发表时间：
1996-05-15
期刊：
影响因子：
20.3
通讯作者：
Baccarani, M
中科院分区：
文献类型：
--
作者：
Silvestri, F;Pipan, C;Baccarani, M
最近推测丙型肝炎病毒（HCV）可能参与恶性B细胞非霍奇金淋巴瘤（NHL）的发病机制。在此观察的基础上，我们试图确定受 B 细胞 NHL 影响的患者中 HCV 感染的患病率，并将我们的分析扩展到过去 30 个月在我们机构见过的所有受淋巴增殖性疾病影响的患者。对五百三十七名未经选择的连续患者进行了研究。通过检测抗HCV抗体和HCV-RNA来调查HCV感染。对 HCV-RNA 阳性标本进行 HCV 基因分型。将感染 HCV 的风险与我们地区一般人群的风险进行了比较。在所有淋巴增殖性疾病中，HCV 感染的患病率和相对风险 (RR) 仅在 B 细胞 NHL 中增加（9%；RR 3.24；P < .0001）。其中，仅在免疫细胞瘤亚组中发现 HCV 患病率较高（30%；RR 10.27；P < .0001），而其他组织型仅偶尔与之相关。由于HCV阳性淋巴瘤在临床上表现为原发性混合冷球蛋白血症（EMC），因此证实了HCV感染与EMC之间的密切相关性，并提供了EMC病理基质与免疫细胞瘤相对应的证据。在 84% 的分析患者中发现了 HCV 基因组序列。病毒基因型在我们地区更为常见。 (C) 1996 年，美国血液学会。
It has been recently hypothesized that the hepatitis C virus (HCV) might be involved in the pathogenesis of malignant B-cell non-Hodgkin's lymphomas (NHL). On the basis of this observation we sought to determine the prevalence of HCV infection in the patients affected by B-cell NHL and extended our analysis to all the patients affected by lymphoproliferative disorders seen at our institution in the last 30 months. Five hundred and thirty-seven unselected, consecutive patients were studied. HCV infection was investigated through detection of anti-HCV antibodies and HCV-RNA. HCV genotyping was performed on HCV-RNA positive specimens. The risk of being infected by HCV was compared with that of the general population of our area. Among all lymphoproliferative disorders, the prevalence and the relative risk (RR) of being infected by HCV were increased only among B-cell NHL (9%; RR 3.24; P < .0001). Among these, a strong prevalence of HCV was found only in the subgroup of immunocytomas (30%; RR 10.27; P < .0001), while other histotypes were associated with it only occasionally. Because HCV-positive lymphomas clinically behave as essential mixed cryoglobulinemia (EMC), the close association between HCV infection and EMC is confirmed, and evidence is provided that the pathological substrate of EMC corresponds to the immunocytoma. HCV genomic sequences were found in 84% of patients analyzed. Viral genotypes were those more frequent in our area. (C) 1996 by The American Society of Hematology.