Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
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DOI：
10.1073/pnas.0308291101
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发表时间：
2004-04-27
影响因子：
11.1
通讯作者：
Holloszy, JO
中科院分区：
文献类型：
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作者：
Fontana, L;Meyer, TE;Holloszy, JO
关于热量限制（CR）对动脉粥样硬化风险的长期影响知之甚少。我们评估了CR对限制食物摄入以减缓衰老的个体动脉粥样硬化危险因素的影响。我们研究了18名平均接受CR治疗6年的人和18名年龄匹配的健康人，他们采用典型的美国饮食。我们测量了血脂和脂蛋白、空腹血糖和胰岛素、血压（BP）、高敏C反应蛋白（CRP）、血小板衍生生长因子AB（PDGF-AB）、身体成分和颈动脉内膜中层厚度（IMT）。CR组比对照组更瘦（体重指数，19.6 +/- 1.9 vs. 25.9 +/- 3.2 kg/m2;体脂百分比，8.7 +/- 7% vs. 24 +/- 8%）。CR组的血清总胆固醇（Tchol）、低密度脂蛋白胆固醇、Tchol/高密度脂蛋白胆固醇（HDL-C）比值、甘油三酯、空腹血糖、空腹胰岛素、CRP、PDFG-AB、收缩压和舒张压均显著低于美国饮食组，而HDL-C则高于美国饮食组。医疗记录表明，CR组的血清脂蛋白和血压水平在典型的美国饮食的个人的通常范围内，并且与对照组相似，在他们开始CR之前。CR组颈动脉IMT较对照组减少约40%。基于一系列危险因素，长期CR似乎对动脉粥样硬化具有强大的保护作用。这一解释得到了低颈动脉IMT的发现的支持。
Little is known regarding the long-term effects of caloric restriction (CR) on the risk for atherosclerosis. We evaluated the effect of CR on risk factors for atherosclerosis in individuals who are restricting food intake to slow aging. We studied 18 individuals who had been on CR for an average of 6 years and 18 age-matched healthy individuals on typical American diets. We measured serum lipids and lipoproteins, fasting plasma glucose and insulin, blood pressure (BP), high-sensitivity C-reactive protein (CRP), plate I et-derived growth factor AB (PDGF-AB), body composition, and carotid artery intima-media thickness (IMT). The CR group were leaner than the comparison group (body mass index, 19.6 +/- 1.9 vs. 25.9 +/- 3.2 kg/m(2); percent body fat, 8.7 +/- 7% vs. 24 +/- 8%). Serum total cholesterol (Tchol), low-density lipoprotein cholesterol, ratio of Tchol to high-density lipoprotein cholesterol (HDL-C), triglycerides, fasting glucose, fasting insulin, CRP, PDFG-AB, and systolic and diastolic BP were all markedly lower, whereas HIDL-C was higher, in the CR than in the American diet group. Medical records indicated that the CR group had serum lipid-lipoprotein and BP levels in the usual range for individuals on typical American diets, and similar to those of the comparison group, before they began CR. Carotid artery IMT was approximate to40% less in the CR group than in the comparison group. Based on a range of risk factors, it appears that long-term CR has a powerful protective effect against atherosclerosis. This interpretation is supported by the finding of a low carotid artery IMT.