Genomic structure of the Salmonella enterica serovar Typhimurium DT 64 bacteriophage ST64T:: Evidence for modular genetic architecture
Genomic structure of the Salmonella enterica serovar Typhimurium DT 64 bacteriophage ST64T:: Evidence for modular genetic architecture
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DOI：
10.1128/jb.185.11.3473-3475.2003
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发表时间：
2003-06-01
影响因子：
3.2
通讯作者：
Heuzenroeder, MW
中科院分区：
文献类型：
--
作者：
Mmolawa, PT;Schmieger, H;Heuzenroeder, MW
测定了一株转化型温和噬菌体ST 64 T的双链DNA基因组的全序列。ST 64 T的40，679-bp基因组序列具有47.5%的总GC含量，并且使人想起许多类胡萝卜素，特别是P22。ST 64 T的推测蛋白与P22蛋白具有高度的序列相似性（>90%），包括功能性血清型转换盒、整合酶、切除酶、Abc 1、Abc 2、早期抗终止（gp 24）、NinD、NinH、NinZ、包装（gp 3和gp 2）、头部（除了gp 26、gp 7、gp 20和gp 16）和尾部蛋白。推测的免疫基因与沙门氏菌血清型鼠伤寒噬菌体L的免疫基因高度相关，而裂解基因与沙门氏菌血清型鼠伤寒噬菌体L的裂解基因几乎相同。肠血清型鼠伤寒PS3。
The complete sequence of the double-stranded DNA genome of a serotype-converting temperate bacteriophage, ST64T, was determined. The 40,679-bp genomic sequence of ST64T has an overall GC content of 47.5% and was reminiscent of a number of lambdoid phages, in particular, P22. Inferred proteins of ST64T which exhibited a high degree of sequence similarity to P22 proteins (>90%) included the functional serotype conversion cassette, integrase, excisionase, Abc1, Abc2, early antitermination (gp24), NinD, NinH, NinZ, packaging (gp3 and gp2), head (with the exception of gp26, gp7, gp20, and gp16), and tail proteins. The putative immunity genes were highly related to those of Salmonella enterica serotype Typhimurium phage L, whereas the lysis genes were almost identical to those of S. enterica serovar Typhimurium PS3.