Effect of Chronic Sodium Depletion on Cerebrospinal Fluid and Plasma Catecholamines
Effect of Chronic Sodium Depletion on Cerebrospinal Fluid and Plasma Catecholamines
复制标题
慢性钠缺乏对脑脊液和血浆儿茶酚胺的影响
DOI：
10.1161/01.hyp.3.2.233
复制
发表时间：
1981
期刊：
影响因子：
8.3
通讯作者：
C. Ferrario
中科院分区：
文献类型：
--
作者：
K. Brosnihan;J. Szilagyi;C. Ferrario
为了测试中枢神经源性因素在钠缺乏状态中的作用，对杂种狗的脑脊液(CSF)去甲肾上腺素、肾上腺素和多巴胺进行了测定，首先是正常钠摄入量(65mEq钠/天)，然后是21天低钠饮食(4mEq/天加利尿剂)。对同一组狗的血浆儿茶酚胺进行了测定。三周的钠耗竭加上利尿剂导致血浆肾素活性、血液浓度和血清蛋白浓度增加24倍。血浆和脑脊液钠均显著降低。钠耗竭后，血浆去甲肾上腺素升高76%，但肾上腺素和多巴胺没有变化。无论是在清醒的动物身上还是在麻醉的动物身上，都观察到了同样的模式。在脑脊液中，去甲肾上腺素在钠耗竭期间增加了44%，而肾上腺素和多巴胺保持不变。脑脊液去甲肾上腺素与脑脊液钠浓度呈负相关，与血浆肾素活性呈正相关。这些观察结果支持这样的观点，即限制饮食钠摄入量和利尿剂治疗的联合过程会导致脑脊液去甲肾上腺素的变化，其方向与中枢去甲肾上腺素能神经元可能过度活动的方向一致。
SUMMARY To test the role of central neurogenic factors in sodium-depleted states, cerebrospinal fluid (CSF) norepinephrine, epinephrine, and dopamine were measured in mongrel dogs first on a normal sodium intake (65 mEq sodium/day) and then on a 21-day regime of low sodium diet (4 mEq/day combined with diuretics). Plasma catecholamines were measured in the same group of dogs. Three weeks of sodium depletion supplemented with diuretics caused a 24-fold increase in plasma renin activity, hemoconcentration, and elevated serum protein concentration. Both plasma and CSF sodium decreased significantly. After sodium depletion, plasma norepinephrine rose 76% but epinephrine and dopamine did not change. The same pattern was observed whether samples were obtained in conscious or anesthetized animals. In CSF, norepinephrine rose 44% during sodium depletion, while epinephrine and dopamine remained unchanged. The CSF norepinephrine was related inversely to the CSF sodium concentration and directly to plasma renin activity. These observations support the view that the combined procedure of restricted dietary sodium intake and diuretic therapy causes alterations in CSF norepinephrine in a direction compatible with possible overactivity of central noradrenergic neurons.