Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain
Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain
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DOI：
10.1016/j.bandl.2014.03.007
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发表时间：
2014-06-01
影响因子：
2.5
通讯作者：
Iriki, Atsushi
中科院分区：
文献类型：
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作者：
Kato, Masaki;Okanoya, Kazuo;Iriki, Atsushi
语言是人类交流的一个特征。已经确定了几种家族语言障碍，并且已经分离出语言障碍的候选基因。比较这些基因在人脑中的表达模式的研究对于进一步了解这些基因是必要的。然而，检查人脑中的基因表达是很困难的。在这项研究中，我们使用非人类灵长类动物（普通狨猴；Callithrix jacchus）作为人脑的生物模型，以研究人类言语和阅读相关基因的表达模式。分析了言语障碍（FoxP2、FoxP1、CNTNAP2 和 CMIP）和阅读障碍（ROBO1、DCDC2 和 KIAA0319）相关基因的表达模式。我们发现这些基因在视觉、听觉和运动系统中表现出重叠的表达模式。我们的结果增强了对语言障碍分子机制的理解。 (C) 2014 年作者。由 Elsevier Inc. 出版。这是一篇遵循 CC BY-NC-ND 许可证 (http://creativecommons.org/licenses/by-nc-nd/3.0/) 的开放获取文章。
Language is a characteristic feature of human communication. Several familial language impairments have been identified, and candidate genes for language impairments already isolated. Studies comparing expression patterns of these genes in human brain are necessary to further understanding of these genes. However, it is difficult to examine gene expression in human brain. In this study, we used a non-human primate (common marmoset; Callithrix jacchus) as a biological model of the human brain to investigate expression patterns of human speech- and reading-related genes. Expression patterns of speech disorder-(FoxP2, FoxP1, CNTNAP2, and CMIP) and dyslexia- (ROBO1, DCDC2, and KIAA0319) related genes were analyzed. We found the genes displayed overlapping expression patterns in the ocular, auditory, and motor systems. Our results enhance understanding of the molecular Mechanisms underlying language impairments. (C) 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).