Importance of lysosomal cysteine proteases in lung disease.
Importance of lysosomal cysteine proteases in lung disease.
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DOI：
10.1186/rr29
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发表时间：
2000
影响因子：
5.8
通讯作者：
Chapman HA
中科院分区：
文献类型：
--
作者：
Wolters PJ;Chapman HA
人类溶酶体半胱氨酸蛋白酶是一个由11个蛋白酶组成的家族，其成员包括组织蛋白酶B、C、H、L和s。几十年来，这些蛋白酶的生物学特性在很大程度上被忽视了，因为它们位于溶酶体中，而且人们认为它们的功能仅限于蛋白质的末端降解。在过去的10年里，这种观点发生了变化，因为人们发现这些蛋白酶在细胞内具有特定的功能。本文综述了其中的一些功能，特别是它们在基质重塑和调节免疫反应中的作用，以及它们与肺部疾病的关系。
The human lysosomal cysteine proteases are a family of 11 proteases whose members include cathepsins B, C, H, L, and S. The biology of these proteases was largely ignored for decades because of their lysosomal location and the belief that their function was limited to the terminal degradation of proteins. In the past 10 years, this view has changed as these proteases have been found to have specific functions within cells. This review highlights some of these functions, specifically their roles in matrix remodeling and in regulating the immune response, and their relationship to lung diseases.