Bmc Medical Genetics Lack of Association between the Chemokine Receptor 5 Polymorphism Ccr5delta32 in Rheumatoid Arthritis and Juvenile Idiopathic Arthritis
Bmc Medical Genetics Lack of Association between the Chemokine Receptor 5 Polymorphism Ccr5delta32 in Rheumatoid Arthritis and Juvenile Idiopathic Arthritis
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Bmc 医学遗传学 类风湿性关节炎和幼年特发性关节炎中趋化因子受体 5 多态性 Ccr5delta32 之间缺乏关联
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通讯作者：
B. Lie
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作者：
Ewald Lindner;Gry Bn;Nordang;E. Melum;B. Flatø;A. Selvaag;E. Thorsby;T. Kvien;Ø. Førre;B. Lie
背景：趋化因子受体CCR5在滑膜T细胞中被检测到水平升高，CCR5基因32 bp的缺失导致了一个无功能的受体。CCR5∆32与类风湿关节炎（RA）之间存在负相关的报道，尽管结果相互矛盾。在青少年特发性关节炎（JIA）中，最近报道了与CCR5的关联。本研究的目的是调查挪威队列中CCR5∆32多态性是否与RA或JIA相关。
Background: The chemokine receptor CCR5 has been detected at elevated levels on synovial T cells, and a 32 bp deletion in the CCR5 gene leads to a non-functional receptor. A negative association between the CCR5∆32 and rheumatoid arthritis (RA) has been reported, although with conflicting results. In juvenile idiopathic arthritis (JIA), an association with CCR5 was recently reported. The purpose of this study was to investigate if the CCR5∆32 polymorphism is associated with RA or JIA in Norwegian cohorts.