Microcirculatory hemodynamics after acute blood loss followed by fresh and banked blood transfusion
Microcirculatory hemodynamics after acute blood loss followed by fresh and banked blood transfusion
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DOI：
10.1016/j.amjsurg.2005.05.041
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发表时间：
2005-09-01
影响因子：
3
通讯作者：
Siemionow, M
中科院分区：
文献类型：
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作者：
Arslan, E;Sierko, E;Siemionow, M
背景：红细胞(RBC)在血液储存过程中会发生构象变化。本研究旨在初步评估这些变化对微循环的影响。方法：采用大鼠提睾肌瓣模型，评价术后体内微循环的变化。取血1ml，然后注入新鲜血液(组I，n=6)和库血(组II，n=6)。每组都经历了3个阶段的评估：基线、停血后和输血后。结果：两组患者的红细胞流速、血管内径、功能毛细血管灌注量、激活的白细胞数均有不同程度的变化，但保存血与新鲜血比较，差异有统计学意义(P
Background: Red.blood cell (RBC) conformational changes occur when blood is stored. This study was designed to be a preliminary evaluation to assess how these changes affect the microcirculation.Methods: The rat cremaster muscle flap model was used to evaluate in vivo microcirculatory changes after. withdrawal of 1 mL blood with subsequent administration of fresh blood (group I, n = 6) and banked blood (group II, n = 6). Each group underwent a 3-stage evaluation: baseline, after blood withdrawal, and after transfusion. Using intravital microscopy, RBC velocity, vessel diameter, functional capillary perfusion, and leukocyte-endothelial interactions were noted.Results: After blood withdrawal, changes in RBC velocity, vessel diameter, functional capillary perfusion, and number of activated leukocytes were observed in both groups, but these changes were, more significant in stored blood compared with fresh blood (P