Bacterial, viral, and fungal infection-related risk of Parkinson's disease: Meta-analysis of cohort and case-control studies
Bacterial, viral, and fungal infection-related risk of Parkinson's disease: Meta-analysis of cohort and case-control studies
复制标题
细菌、病毒和真菌感染相关的帕金森病风险：队列和病例对照研究的荟萃分析
DOI：
10.1002/brb3.1549
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发表时间：
2020-02-04
影响因子：
3.1
通讯作者：
Chen, Lifen
中科院分区：
文献类型：
--
作者：
Wang, Hui;Liu, Xi;Chen, Lifen
目标 最近的研究表明，患有各种细菌、病毒和真菌感染的患者患帕金森病 (PD) 的风险可能增加。然而，每种特定感染的患者发生 PD 的风险各不相同。这项荟萃分析估计了各种感染与 PD 风险之间的关联。方法检索了 1965 年 1 月至 2019 年 10 月在 PubMed 和 EMBASE 数据库中发表的文献。使用随机/固定效应模型提取和汇总数据。还进行了敏感性分析和荟萃回归来分析异质性的来源。通过修剪和填充来估计发表偏倚。结果 纳入了 6,609 项研究中的 23 项。幽门螺杆菌（HP；汇总 OR = 1.653、1.426-1.915，p < .001）、丙型肝炎病毒（HCV；汇总 OR = 1.195、1.012-1.410，p = .035）、马拉色菌（汇总 OR = 1.694、1.367-2.100，p < .001）和肺炎（合并 OR = 1.595、1.020-2.493、p = .041）感染与 PD 风险增加相关。流感病毒、疱疹病毒、乙型肝炎病毒、猩红热、腮腺炎病毒、水痘、百日咳、德国麻疹和麻疹与PD风险无关。 HCV 抗病毒治疗后，HCV 感染患者发生 PD 的风险降低 (OR = 0.672, 0.571-0.791, p < .001)。纳入的研究存在显着的异质性。结论感染HP、HCV、马拉色菌、肺炎球菌的患者发生PD的风险可能增加。 HCV 抗病毒治疗可以降低 PD 风险。
Aims Recent studies showed that patients with various bacterial, viral, and fungal infections might be at increased risk of Parkinson's disease (PD). However, the risk of PD in patients with each specific infection varied. This meta-analysis estimated the association between various infections and PD risk.Methods Literature published from January 1965 to October 2019 in PubMed and EMBASE databases was searched. Data were extracted and pooled using random/fixed effects model. Sensitivity analysis and meta-regression were also performed to analyze the source of heterogeneity. Publication bias was estimated by the trim and fill.Results Twenty-three out of 6,609 studies were included. Helicobacter pylori (HP; pooled OR = 1.653, 1.426-1.915, p < .001), hepatitis C virus (HCV; pooled OR = 1.195, 1.012-1.410, p = .035), Malassezia (pooled OR = 1.694, 1.367-2.100, p < .001), and pneumoniae (pooled OR = 1.595, 1.020-2.493, p = .041) infection were associated with increased PD risk. Influenza virus, herpes virus, hepatitis B virus, scarlet fever, mumps virus, chicken pox, pertussis, German measles, and measles were not associated with PD risk. After antiviral treatment against HCV reduced the risk of PD in patients with HCV infection (OR = 0.672, 0.571-0.791, p < .001). Significant heterogeneity exists among the included studies.Conclusion Patients with infection of HP, HCV, Malassezia, pneumoniae might be an increased risk of PD. Antiviral treatment of HCV could reduce the risk of PD.