The epigenetics of brain tumors.
The epigenetics of brain tumors.
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DOI：
10.1007/978-1-61779-612-8_8
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Taylor, Michael D
中科院分区：
文献类型：
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作者：
Dubuc, Adrian M;Mack, Stephen;Taylor, Michael D
胶质母细胞瘤、髓母细胞瘤和室管膜瘤代表了成人和儿童脑肿瘤的分子和临床不同形式。虽然每种肿瘤都表现出遗传、转录和细胞遗传学异质性，但这些肿瘤的表观基因组最近才成为人们感兴趣的主要领域。在这里，我们描述了我们对脑肿瘤表观遗传学理解的进展，重点关注 DNA 甲基化、组蛋白修饰和 microRNA 失调，这些因素导致了这些疾病的发病机制。
Glioblastoma, medulloblastoma, and ependymoma represent molecularly and clinically diverse forms of adult and pediatric brain tumors. While each tumor displays genetic, transcriptional, and cytogenetic heterogeneity, the epigenome of these tumors has only recently emerged as a major field of interest. Here, we describe advances in our understanding of the epigenetics of brain tumors, focusing on DNA methylation, histone modifications, and microRNA deregulation which contribute to the pathogenesis of these diseases.