Association between serum concentrations of 25-hydroxyvitamin D and gingival inflammation
Association between serum concentrations of 25-hydroxyvitamin D and gingival inflammation
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DOI：
10.1093/ajcn/82.3.575
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发表时间：
2005-09-01
影响因子：
7.1
通讯作者：
Bischoff-Ferrari, HA
中科院分区：
文献类型：
--
作者：
Dietrich, T;Nunn, M;Bischoff-Ferrari, HA
背景：维生素D在体外和动物实验中已被证明具有免疫调节作用。然而，炎症性疾病的临床研究数据很少。目的：本研究的目的是评估血清25-羟基维生素D [25(OH)D]浓度与牙龈炎症的关系。设计：我们分析了来自第三次全国健康与营养检查调查的6700名13岁至90岁从不吸烟者的77 503个牙龈单位（牙齿）的数据。多逻辑回归模型调整了受试者和特定地点的相关变量，包括年龄、性别、种族、收入、体重指数、糖尿病、女性口服避孕药和激素替代疗法的使用、维生素c的摄入、缺牙、全冠覆盖率、结石的存在、牙科就诊频率、牙科检查人员和调查阶段。使用广义估计方程来解释受试者内部的相关观察结果。结果：与处于最低25(OH)D五分位数的受试者进行比较。在25(OH)D最高的五分位数中的位点为20% （95% CI: 8%）。31%)牙龈探查出血的可能性较低（P < 0.001）。在整个25(OH)D范围内，这种关联似乎是线性的。在不同种族或民族群体中是一致的，在男性和女性以及服用和不服用维生素和矿物质补充剂的人群中是相似的。结论：维生素D可能通过其抗炎作用降低牙龈炎症的易感性。牙龈炎可能是评估维生素D抗炎作用的一个有用的临床模型。
Background: Vitamin D has been shown to have immunomodulatory effects in in vitro and in animal studies. However, data from clinical studies of inflammatory diseases are scarce.Objective: The purpose of this study was to evaluate the association between serum concentrations of 25-hydroxyvitamin D [25(OH)D] and gingival inflammation.Design: We analyzed data from 77 503 gingival units (teeth) in 6700 never smokers aged 13 to > 90 y from the third National Health and Nutrition Examination Survey. Multiple logistic regression models adjusted for subject- and site-specific covariates included age, sex, race-ethnicity, income, body mass index, diabetes, use of oral contraceptives and hormone replacement therapy among women, intake of vitamin C. missing teeth, full crown coverage, presence of calculus, frequency of dental visits, and dental examiner and survey phase. Generalized estimating equations were used to account for correlated observations within subjects.Results: Compared with sites in subjects in the lowest 25(OH)D quintile. sites in Subjects in the highest 25(OH)D quintile were 20% (95% CI: 8%. 31%) less likely to bleed on gingival probing (P for trend < 0.001). The association appeared to be linear over the entire 25(OH)D range. was consistent across racial or ethnic groups, and was similar among men and women as well as among users and nonusers of vitamin and mineral supplements.Conclusions: Vitamin D may reduce susceptibility to gingival inflamination through its anti inflammatory effects. Gingivitis may be a useful clinical model to evaluate the antinflammatory effects, of vitamin D.