DYNAMICS OF THE HIPPOCAMPAL ENSEMBLE CODE FOR SPACE
DYNAMICS OF THE HIPPOCAMPAL ENSEMBLE CODE FOR SPACE
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DOI：
10.1126/science.8351520
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发表时间：
1993-08-20
期刊：
影响因子：
56.9
通讯作者：
MCNAUGHTON, BL
中科院分区：
文献类型：
--
作者：
WILSON, MA;MCNAUGHTON, BL
对73到148个大鼠海马神经元的记录被用来准确地预测动物在环境中的运动，这证实了海马体传递的是一个定位的整体代码。在一个新的空间中，集成码最初不太健壮，但随着探索而迅速改进。在此期间，许多抑制性细胞的活动受到抑制，这表明新的空间信息在海马回路中创造了有利于突触修饰的条件，这些突触修饰被认为与学习有关。为新环境开发新的种群代码并没有实质性地改变熟悉环境的代码，这表明两种空间表征之间的干扰非常小。这里概述的并行记录方法使得在独特的行为事件过程中神经元相互作用的动力学研究成为可能。
Ensemble recordings of 73 to 148 rat hippocampal neurons were used to predict accurately the animals' movement through their environment, which confirms that the hippocampus transmits an ensemble code for location. In a novel space, the ensemble code was initially less robust but improved rapidly with exploration. During this period, the activity of many inhibitory cells was suppressed, which suggests that new spatial information creates conditions in the hippocampal circuitry that are conducive to the synaptic modification presumed to be involved in learning. Development of a new population code for a novel environment did not substantially alter the code for a familiar one, which suggests that the interference between the two spatial representations was very small. The parallel recording methods outlined here make possible the study of the dynamics of neuronal interactions during unique behavioral events.