Black chokeberry juice (Aronia melanocarpa) reduces incidences of urinary tract infection among nursing home residents in the long term-a pilot study
Black chokeberry juice (Aronia melanocarpa) reduces incidences of urinary tract infection among nursing home residents in the long term-a pilot study
复制标题
DOI：
10.1016/j.nutres.2014.05.005
复制
发表时间：
2014-06-01
影响因子：
4.5
通讯作者：
Slimestad, Rune
中科院分区：
文献类型：
--
作者：
Handeland, Maria;Grude, Nils;Slimestad, Rune
尿路感染（UTI）是养老院的主要问题，治疗的主要方法是抗生素。对抗菌剂耐药的尿路病原体的日益流行刺激了对特定营养素的兴趣，例如蔓越莓，以防止复发性UTI。黑樱桃（Aronia melanocarpa [Michx] Elliott）是酚类化合物的丰富来源，因此，黑樱桃汁的饮食摄入可以减少需要医疗的UTI的发生率。在这项试点研究中，我们检查了6家疗养院的居民中接受药物治疗的UTI的频率，这些疗养院在6个月的交叉干预期间提供了黑樱桃汁或安慰剂。这些居民在3个月的时间里喝安慰剂饮料，然后在接下来的3个月里喝樱桃汁（A组），反之亦然（B组）。果汁的特点是高含量的总酚（715毫克没食子酸当量，100 mL（-1）），包括B型原花青素，花青素，和绿原酸。A组（n = 110）和B组（n = 126）的居民每人每天摄入的樱桃汁分别为156 mL和89 mL。尿路感染占研究期间所有经药物治疗感染的55%。结果显示，UTI的频率或抗生素的总使用量没有立即减少;然而，在随后的3个月果汁给药期间，两组中均观察到UTI的抗生素减少。UTI发生率A组降低55%，B组降低38%。未观察到其他感染或抗菌药物使用的变化。(C)2014爱思唯尔公司All rights reserved.
Urinary tract infection (UTI) is a major problem in nursing homes, and the mainstay of treatment is antibiotics. The increasing prevalence of uropathogens resistant to antimicrobial agents has stimulated interest in specific nutrients, for example, cranberries, to prevent recurring UTI. Black chokeberry (Aronia melanocarpa [Michx] Elliott) is a rich source of phenolics, and thus, dietary intake of black chokeberry juice may reduce the incidences of UTI requiring medical treatment. In this pilot study, we examined the frequency of medically treated UTI among residents in 6 nursing homes who were offered black chokeberry juice or a placebo during a 6-month crossover intervention. The residents were offered a placebo drink for a 3-month period followed by chokeberry juice for the next 3-months (group A) or vice versa (group B). The juice was characterized by a high content of total phenolics (715 mg gallic acid equivalent, 100 mL(-1)), including B-type procyanidins, anthocyanins, and chlorogenic acids. Daily intake of chokeberry juice was 156 mL per resident in group A (n = 110) and 89 mL per resident in group B (n = 126). Urinary tract infection comprised 55% of all medically treated infections during the study period. The results revealed no immediate reduction in the frequency of UTI or the total use of antibiotics; however, during the subsequent 3-month period of juice administration, a reduction in antibiotics toward UTI was observed in both groups. The incidence of UTI was reduced by 55% in group A and 38% in group B. No changes in other infections or in use of prophylactics were observed. (C) 2014 Elsevier Inc. All rights reserved.